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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characterization of Human Adrenal Steroidogenesis during Fetal Development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Thomas P van der Meer
  • Francisco Artacho-Cordón
  • Dick F Swaab
  • Dicky Struik
  • Konstantinos C Makris
  • Bruce H R Wolffenbuttel
  • Hanne Frederiksen
  • Jana V van Vliet-Ostaptchouk
Vis graf over relationer

Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m², respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood-brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.

OriginalsprogEngelsk
TidsskriftInternational Journal of Environmental Research and Public Health
Vol/bind14
Udgave nummer9
Sider (fra-til) E1059
ISSN1661-7827
DOI
StatusUdgivet - 13 sep. 2017

ID: 51724686