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Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition

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Spark, J., Gawęda, Ł., Allott, K., Hartmann, J. A., Jack, B. N., Koren, D., Lavoie, S., Li, E., McGorry, P. D., Parnas, J., Polari, A., Sass, L. A., Whitford, T., & Nelson, B. (2021). Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition. Schizophrenia Research, 228, 19-28. https://doi.org/10.1016/j.schres.2020.11.061

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Spark, Jessica ; Gawęda, Łukasz ; Allott, Kelly ; Hartmann, Jessica A ; Jack, Bradley N ; Koren, Dan ; Lavoie, Suzie ; Li, Emily ; McGorry, Patrick D ; Parnas, Josef ; Polari, Andrea ; Sass, Louis A ; Whitford, Thomas ; Nelson, Barnaby. / Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk : The role of basic self-disturbance and neurocognition. I: Schizophrenia Research. 2021 ; Bind 228. s. 19-28.

Bibtex

@article{b0bc0949fa3441a381a0b21b587927cd,
title = "Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition",
abstract = "INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms of its predictive validity as suggested by studies showing schizophrenia spectrum patients have more unfavourable outcomes compared to other psychotic disorders. The present study aimed to investigate whether basic self-disturbances and neurocognitive processes that have been linked to psychosis risk have discriminative power for schizophrenia spectrum disorders in patients presenting with first episode psychosis (FEP) and at ultra-high risk for psychosis (UHR).METHODS: 38 FEP patients, 48 UHR patients, and 33 healthy controls were assessed for basic self-disturbances (using the Examination of Anomalous Self-Experience, EASE, interview), source monitoring and aberrant salience (behavioural tasks to measure neurocognitive constructs). Clinical groups were divided into patients with schizophrenia spectrum disorders and those with other non-spectrum disorders and were further compared on measures controlling for symptom severity and age.RESULTS: Basic self-disturbances distinguished schizophrenia spectrum from non-spectrum disorders in the 'FEP only' sample, F = 19.76, p < 0.001, η2partial = 0.37, and also in the combined UHR/FEP sample, F = 23.56, p < 0.001, η2partial = 0.22. Additionally, some processes related to source monitoring deficits were elevated in schizophrenia spectrum disorders. In contrast, the two groups (schizophrenia spectrum vs other diagnoses) performed similarly in aberrant salience tasks. Comparable results were obtained for analyses performed with an FEP/UHR combined sample and the 'FEP only' sample.DISCUSSION: Basic self-disturbances at the phenomenological level and source monitoring deficits on the neurocognitive level may be useful in identifying risk of schizophrenia spectrum disorders at the earliest clinical presentation.",
keywords = "Health Sciences, Aberrant salience, Clinical high risk, Schizophrenia spectrum, Self disturbance, Source monitoring",
author = "Jessica Spark and {\L}ukasz Gaw{\c e}da and Kelly Allott and Hartmann, {Jessica A} and Jack, {Bradley N} and Dan Koren and Suzie Lavoie and Emily Li and McGorry, {Patrick D} and Josef Parnas and Andrea Polari and Sass, {Louis A} and Thomas Whitford and Barnaby Nelson",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.schres.2020.11.061",
language = "English",
volume = "228",
pages = "19--28",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk

T2 - The role of basic self-disturbance and neurocognition

AU - Spark, Jessica

AU - Gawęda, Łukasz

AU - Allott, Kelly

AU - Hartmann, Jessica A

AU - Jack, Bradley N

AU - Koren, Dan

AU - Lavoie, Suzie

AU - Li, Emily

AU - McGorry, Patrick D

AU - Parnas, Josef

AU - Polari, Andrea

AU - Sass, Louis A

AU - Whitford, Thomas

AU - Nelson, Barnaby

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms of its predictive validity as suggested by studies showing schizophrenia spectrum patients have more unfavourable outcomes compared to other psychotic disorders. The present study aimed to investigate whether basic self-disturbances and neurocognitive processes that have been linked to psychosis risk have discriminative power for schizophrenia spectrum disorders in patients presenting with first episode psychosis (FEP) and at ultra-high risk for psychosis (UHR).METHODS: 38 FEP patients, 48 UHR patients, and 33 healthy controls were assessed for basic self-disturbances (using the Examination of Anomalous Self-Experience, EASE, interview), source monitoring and aberrant salience (behavioural tasks to measure neurocognitive constructs). Clinical groups were divided into patients with schizophrenia spectrum disorders and those with other non-spectrum disorders and were further compared on measures controlling for symptom severity and age.RESULTS: Basic self-disturbances distinguished schizophrenia spectrum from non-spectrum disorders in the 'FEP only' sample, F = 19.76, p < 0.001, η2partial = 0.37, and also in the combined UHR/FEP sample, F = 23.56, p < 0.001, η2partial = 0.22. Additionally, some processes related to source monitoring deficits were elevated in schizophrenia spectrum disorders. In contrast, the two groups (schizophrenia spectrum vs other diagnoses) performed similarly in aberrant salience tasks. Comparable results were obtained for analyses performed with an FEP/UHR combined sample and the 'FEP only' sample.DISCUSSION: Basic self-disturbances at the phenomenological level and source monitoring deficits on the neurocognitive level may be useful in identifying risk of schizophrenia spectrum disorders at the earliest clinical presentation.

AB - INTRODUCTION: The distinction between the schizophrenia spectrum and other types of disorders may be clinically relevant in terms of its predictive validity as suggested by studies showing schizophrenia spectrum patients have more unfavourable outcomes compared to other psychotic disorders. The present study aimed to investigate whether basic self-disturbances and neurocognitive processes that have been linked to psychosis risk have discriminative power for schizophrenia spectrum disorders in patients presenting with first episode psychosis (FEP) and at ultra-high risk for psychosis (UHR).METHODS: 38 FEP patients, 48 UHR patients, and 33 healthy controls were assessed for basic self-disturbances (using the Examination of Anomalous Self-Experience, EASE, interview), source monitoring and aberrant salience (behavioural tasks to measure neurocognitive constructs). Clinical groups were divided into patients with schizophrenia spectrum disorders and those with other non-spectrum disorders and were further compared on measures controlling for symptom severity and age.RESULTS: Basic self-disturbances distinguished schizophrenia spectrum from non-spectrum disorders in the 'FEP only' sample, F = 19.76, p < 0.001, η2partial = 0.37, and also in the combined UHR/FEP sample, F = 23.56, p < 0.001, η2partial = 0.22. Additionally, some processes related to source monitoring deficits were elevated in schizophrenia spectrum disorders. In contrast, the two groups (schizophrenia spectrum vs other diagnoses) performed similarly in aberrant salience tasks. Comparable results were obtained for analyses performed with an FEP/UHR combined sample and the 'FEP only' sample.DISCUSSION: Basic self-disturbances at the phenomenological level and source monitoring deficits on the neurocognitive level may be useful in identifying risk of schizophrenia spectrum disorders at the earliest clinical presentation.

KW - Health Sciences

KW - Aberrant salience

KW - Clinical high risk

KW - Schizophrenia spectrum

KW - Self disturbance

KW - Source monitoring

UR - http://www.scopus.com/inward/record.url?scp=85099219660&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2020.11.061

DO - 10.1016/j.schres.2020.11.061

M3 - Journal article

C2 - 33434729

VL - 228

SP - 19

EP - 28

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 61747797