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Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

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Harvard

Lin, G-L, Drysdale, SB, Snape, MD, O'Connor, D, Brown, A, MacIntyre-Cockett, G, Mellado-Gomez, E, de Cesare, M, Bonsall, D, Ansari, MA, Öner, D, Aerssens, J, Butler, C, Bont, L, Openshaw, P, Martinón-Torres, F, Nair, H, Bowden, R, Golubchik, T, Pollard, AJ, RESCEU Investigators & Fischer, TK 2021, 'Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus', Nature Communications, bind 12, nr. 1, 5125, s. 5125. https://doi.org/10.1038/s41467-021-25265-4

APA

Lin, G-L., Drysdale, S. B., Snape, M. D., O'Connor, D., Brown, A., MacIntyre-Cockett, G., Mellado-Gomez, E., de Cesare, M., Bonsall, D., Ansari, M. A., Öner, D., Aerssens, J., Butler, C., Bont, L., Openshaw, P., Martinón-Torres, F., Nair, H., Bowden, R., Golubchik, T., ... Fischer, T. K. (2021). Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus. Nature Communications, 12(1), 5125. [5125]. https://doi.org/10.1038/s41467-021-25265-4

CBE

Lin G-L, Drysdale SB, Snape MD, O'Connor D, Brown A, MacIntyre-Cockett G, Mellado-Gomez E, de Cesare M, Bonsall D, Ansari MA, Öner D, Aerssens J, Butler C, Bont L, Openshaw P, Martinón-Torres F, Nair H, Bowden R, Golubchik T, Pollard AJ, RESCEU Investigators , Fischer TK. 2021. Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus. Nature Communications. 12(1):5125. https://doi.org/10.1038/s41467-021-25265-4

MLA

Vancouver

Author

Lin, Gu-Lung ; Drysdale, Simon B ; Snape, Matthew D ; O'Connor, Daniel ; Brown, Anthony ; MacIntyre-Cockett, George ; Mellado-Gomez, Esther ; de Cesare, Mariateresa ; Bonsall, David ; Ansari, M Azim ; Öner, Deniz ; Aerssens, Jeroen ; Butler, Christopher ; Bont, Louis ; Openshaw, Peter ; Martinón-Torres, Federico ; Nair, Harish ; Bowden, Rory ; Golubchik, Tanya ; Pollard, Andrew J ; RESCEU Investigators ; Fischer, Thea Kølsen. / Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus. I: Nature Communications. 2021 ; Bind 12, Nr. 1. s. 5125.

Bibtex

@article{0db4625d5ca84039b98d7f9a7718971c,
title = "Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus",
abstract = "Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.",
author = "Gu-Lung Lin and Drysdale, {Simon B} and Snape, {Matthew D} and Daniel O'Connor and Anthony Brown and George MacIntyre-Cockett and Esther Mellado-Gomez and {de Cesare}, Mariateresa and David Bonsall and Ansari, {M Azim} and Deniz {\"O}ner and Jeroen Aerssens and Christopher Butler and Louis Bont and Peter Openshaw and Federico Martin{\'o}n-Torres and Harish Nair and Rory Bowden and Tanya Golubchik and Pollard, {Andrew J} and {RESCEU Investigators} and Fischer, {Thea K{\o}lsen}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
day = "26",
doi = "10.1038/s41467-021-25265-4",
language = "English",
volume = "12",
pages = "5125",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

AU - Lin, Gu-Lung

AU - Drysdale, Simon B

AU - Snape, Matthew D

AU - O'Connor, Daniel

AU - Brown, Anthony

AU - MacIntyre-Cockett, George

AU - Mellado-Gomez, Esther

AU - de Cesare, Mariateresa

AU - Bonsall, David

AU - Ansari, M Azim

AU - Öner, Deniz

AU - Aerssens, Jeroen

AU - Butler, Christopher

AU - Bont, Louis

AU - Openshaw, Peter

AU - Martinón-Torres, Federico

AU - Nair, Harish

AU - Bowden, Rory

AU - Golubchik, Tanya

AU - Pollard, Andrew J

AU - RESCEU Investigators

A2 - Fischer, Thea Kølsen

N1 - © 2021. The Author(s).

PY - 2021/8/26

Y1 - 2021/8/26

N2 - Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.

AB - Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.

UR - http://www.scopus.com/inward/record.url?scp=85113609359&partnerID=8YFLogxK

U2 - 10.1038/s41467-021-25265-4

DO - 10.1038/s41467-021-25265-4

M3 - Journal article

C2 - 34446722

VL - 12

SP - 5125

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5125

ER -

ID: 67384531