@article{80f075f2c7394c4484ea60a0eafdb997,
title = "Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2",
abstract = "Recent studies have revealed recurrent mutations of the NOTCH1, SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive, chemorefractory cases. Nevertheless, it is currently unknown whether their presence may differ in subsets of patients carrying stereotyped B-cell receptors and also exhibiting distinct prognoses. Here, we analyzed the mutation status of NOTCH1, SF3B1 and BIRC3 in three subsets with particularly poor prognosis, that is, subset #1, #2 and #8, aiming to explore links between genetic aberrations and immune signaling. A remarkably higher frequency of SF3B1 mutations was revealed in subset #2 (44%) versus subset #1 and #8 (4.6% and 0%, respectively; P",
keywords = "Cohort Studies, DNA, Neoplasm, Follow-Up Studies, Humans, Inhibitor of Apoptosis Proteins, Leukemia, Lymphocytic, Chronic, B-Cell, Mutation, Phosphoproteins, Polymerase Chain Reaction, Prognosis, Receptor, Notch1, Ribonucleoprotein, U2 Small Nuclear, Survival Rate, Tumor Markers, Biological",
author = "Strefford, {J C} and L-A Sutton and P Baliakas and A Agathangelidis and J Mal{\v c}{\'i}kov{\'a} and K Plevova and L Scarf{\'o} and Davis, {Zachary James} and E Stalika and D Cortese and N Cahill and Pedersen, {L B} and {di Celle}, {P F} and T Tzenou and C Geisler and P Panagiotidis and Langerak, {A W} and N Chiorazzi and S Pospisilova and D Oscier and F Davi and C Belessi and L Mansouri and P Ghia and K Stamatopoulos and R Rosenquist",
year = "2013",
month = nov,
doi = "10.1038/leu.2013.98",
language = "English",
volume = "27",
pages = "2196--9",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Springer Nature",
number = "11",
}