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Distinct immune phenotypes in infants developing asthma during childhood

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@article{ba136208cb264080b26e9530a69d5a83,
title = "Distinct immune phenotypes in infants developing asthma during childhood",
abstract = "Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.",
author = "Thysen, {Anna Hammerich} and Johannes Waage and Larsen, {Jeppe Madura} and Rasmussen, {Morten Arendt} and Jakob Stokholm and Bo Chawes and Fink, {Nadia Rahman} and Pedersen, {Tine Marie} and Helene Wolsk and Sunna Thorsteinsdottir and Thomas Litman and Harald Renz and Klaus B{\o}nnelykke and Hans Bisgaard and Susanne Brix",
note = "Copyright {\circledC} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2020",
month = "2",
day = "5",
doi = "10.1126/scitranslmed.aaw0258",
language = "English",
volume = "12",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "529",

}

RIS

TY - JOUR

T1 - Distinct immune phenotypes in infants developing asthma during childhood

AU - Thysen, Anna Hammerich

AU - Waage, Johannes

AU - Larsen, Jeppe Madura

AU - Rasmussen, Morten Arendt

AU - Stokholm, Jakob

AU - Chawes, Bo

AU - Fink, Nadia Rahman

AU - Pedersen, Tine Marie

AU - Wolsk, Helene

AU - Thorsteinsdottir, Sunna

AU - Litman, Thomas

AU - Renz, Harald

AU - Bønnelykke, Klaus

AU - Bisgaard, Hans

AU - Brix, Susanne

N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2020/2/5

Y1 - 2020/2/5

N2 - Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.

AB - Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.

U2 - 10.1126/scitranslmed.aaw0258

DO - 10.1126/scitranslmed.aaw0258

M3 - Journal article

VL - 12

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 529

ER -

ID: 59409018