TY - JOUR
T1 - Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults
T2 - a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition
AU - Wheeler, Michael J
AU - Green, Daniel J
AU - Ellis, Kathryn A
AU - Cerin, Ester
AU - Heinonen, Ilkka
AU - Naylor, Louise H
AU - Larsen, Robyn
AU - Wennberg, Patrik
AU - Boraxbekk, Carl-Johan
AU - Lewis, Jaye
AU - Eikelis, Nina
AU - Lautenschlager, Nicola T
AU - Kingwell, Bronwyn A
AU - Lambert, Gavin
AU - Owen, Neville
AU - Dunstan, David W
N1 - © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - BACKGROUND: Sedentary behaviour is associated with impaired cognition, whereas exercise can acutely improve cognition.OBJECTIVE: We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cognition in older adults.METHODS: Sedentary overweight/obese older adults with normal cognitive function (n=67, 67±7 years, 31.2±4.1 kg/m2) completed three conditions (6-day washout): SIT (sitting): uninterrupted sitting (8 hours, control); EX+SIT (exercise + sitting): sitting (1 hour), moderate-intensity walking (30 min), uninterrupted sitting (6.5 hours); and EX+BR (exercise + breaks): sitting (1 hour), moderate-intensity walking (30 min), sitting interrupted every 30 min with 3 min of light-intensity walking (6.5 hours). Cognitive testing (Cogstate) was completed at four time points assessing psychomotor function, attention, executive function, visual learning and working memory. Serum brain-derived neurotrophic growth factor (BDNF) was assessed at six time points. The 8-hour net area under the curve (AUC) was calculated for each outcome.RESULTS: Working memory net AUC z-score·hour (95% CI) was improved in EX+BR with a z-score of +28 (-26 to +81), relative to SIT, -25 (-79 to +29, p=0.04 vs EX+BR). Executive function net AUC was improved in EX+SIT, -8 (- 71 to +55), relative to SIT, -80 (-142 to -17, p=0.03 vs EX+SIT). Serum BDNF net AUC ng/mL·hour (95% CI) was increased in both EX+SIT, +171 (-449 to +791, p=0.03 vs SIT), and EX+BR, +139 (-481 to +759, p=0.045 vs SIT), relative to SIT, -227 (-851 to +396).CONCLUSION: A morning bout of moderate-intensity exercise improves serum BDNF and working memory or executive function in older adults, depending on whether or not subsequent sitting is also interrupted with intermittent light-intensity walking.TRIAL REGISTRATION NUMBER: ACTRN12614000737639.
AB - BACKGROUND: Sedentary behaviour is associated with impaired cognition, whereas exercise can acutely improve cognition.OBJECTIVE: We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cognition in older adults.METHODS: Sedentary overweight/obese older adults with normal cognitive function (n=67, 67±7 years, 31.2±4.1 kg/m2) completed three conditions (6-day washout): SIT (sitting): uninterrupted sitting (8 hours, control); EX+SIT (exercise + sitting): sitting (1 hour), moderate-intensity walking (30 min), uninterrupted sitting (6.5 hours); and EX+BR (exercise + breaks): sitting (1 hour), moderate-intensity walking (30 min), sitting interrupted every 30 min with 3 min of light-intensity walking (6.5 hours). Cognitive testing (Cogstate) was completed at four time points assessing psychomotor function, attention, executive function, visual learning and working memory. Serum brain-derived neurotrophic growth factor (BDNF) was assessed at six time points. The 8-hour net area under the curve (AUC) was calculated for each outcome.RESULTS: Working memory net AUC z-score·hour (95% CI) was improved in EX+BR with a z-score of +28 (-26 to +81), relative to SIT, -25 (-79 to +29, p=0.04 vs EX+BR). Executive function net AUC was improved in EX+SIT, -8 (- 71 to +55), relative to SIT, -80 (-142 to -17, p=0.03 vs EX+SIT). Serum BDNF net AUC ng/mL·hour (95% CI) was increased in both EX+SIT, +171 (-449 to +791, p=0.03 vs SIT), and EX+BR, +139 (-481 to +759, p=0.045 vs SIT), relative to SIT, -227 (-851 to +396).CONCLUSION: A morning bout of moderate-intensity exercise improves serum BDNF and working memory or executive function in older adults, depending on whether or not subsequent sitting is also interrupted with intermittent light-intensity walking.TRIAL REGISTRATION NUMBER: ACTRN12614000737639.
KW - Aged
KW - Area Under Curve
KW - Brain-Derived Neurotrophic Factor/blood
KW - Cross-Over Studies
KW - Executive Function/physiology
KW - Exercise/psychology
KW - Humans
KW - Memory, Short-Term/physiology
KW - Middle Aged
KW - Obesity/physiopathology
KW - Overweight/physiopathology
KW - Sitting Position
KW - Walking/physiology
KW - ageing
KW - exercise
KW - brain
KW - sedentary
UR - http://www.scopus.com/inward/record.url?scp=85065055578&partnerID=8YFLogxK
U2 - 10.1136/bjsports-2018-100168
DO - 10.1136/bjsports-2018-100168
M3 - Journal article
C2 - 31036563
SN - 0306-3674
VL - 54
SP - 776
EP - 781
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 13
ER -