Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Disinfection trials with terbinafine-susceptible and -resistant dermatophytes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Azole Resistance in Aspergillus fumigatus. The first 2-year's Data from the Danish National Surveillance Study, 2018-2020

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Would you like to purchase a rodent with dermatophytes?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Differences in epidemiology of candidaemia in the Nordic countries - what is to blame?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Azole Resistance in Aspergillus fumigatus. The first 2-year's Data from the Danish National Surveillance Study, 2018-2020

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lack of relationship between genotype and virulence in Candida species

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Intensive Care Antifungal Stewardship Programme Based on T2Candida PCR and Candida Mannan Antigen: A Prospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Update 2016-2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Kristoffer Nagy Skaastrup
  • Karen Marie Thyssen Astvad
  • Maiken Cavling Arendrup
  • Gregor Borut Ernst Jemec
  • Ditte Marie Lindhardt Saunte
Vis graf over relationer

BACKGROUND: Treatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine-resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis.

OBJECTIVES: The aim of this study is to describe the effect of commonplace disinfection methods using socks pieces inoculated with terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp.

METHODS: Sock pieces were inoculated with seven terbinafine-resistant isolates of Trichophyton spp. with known mutations in the SQLE-gene (T. rubrum (n=3), T. interdigitale (n=1), and T. indotineae (n=3)) and six terbinafine-susceptible isolates of Trichophyton spp. (T. rubrum (n=3) and T. interdigitale (n=3)). Methods of disinfection included soaking in a quaternary ammonium (QAC) detergent (0.5, 2, and 24 hours), freezing at -20°C (0.5, 12, and 24 hours), domestic washing (40°C with detergent), and steam washing (40°C with detergent). Sock pieces were cultured for 4 weeks following disinfection. The primary end point was no growth at the end of week 4.

RESULTS: Soaking in QAC-detergent for 24 hours procured at disinfectant rate of 100% (13/13), whilst soaking in 0.5 and 2 hours had a disinfectant rate of 46% (6/13) and 85% (11/13), respectively. Domestic washing (40°C with detergent) produced a disinfectant rate of 7.7% (1/13). Freezing at -20°C (0.5, 12, and 24 hours) and steam washing (40°C with detergent) had no disinfectant properties.

CONCLUSIONS: Soaking socks contaminated with dermatophytes in a QAC-detergent for 24 hours disinfects socks.

OriginalsprogEngelsk
TidsskriftMycoses
ISSN0933-7407
DOI
StatusE-pub ahead of print - 10 maj 2022

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 77896889