TY - JOUR
T1 - Disease Mechanisms in Atopic Dermatitis
T2 - A Review of Aetiological Factors
AU - Thyssen, Jacob P
AU - Rinnov, Maria Rasmussen
AU - Vestergaard, Christian
PY - 2020/6/9
Y1 - 2020/6/9
N2 - Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15-20% of children and 3-5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease.
AB - Atopic dermatitis is a prevalent inflammatory skin condition characterized by itch and dry skin, which affects 15-20% of children and 3-5% of adults. This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease.
KW - Aetiology
KW - Atopic dermatitis
KW - Pathomechanism
KW - Pathophysiology
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=85086345957&partnerID=8YFLogxK
U2 - 10.2340/00015555-3512
DO - 10.2340/00015555-3512
M3 - Review
C2 - 32412642
SN - 0001-5555
VL - 100
SP - 341
EP - 348
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 100-year theme Atopic dermatitis
M1 - adv00162
ER -