Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. APOE and dementia - resequencing and genotyping in 105,597 individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Shift work and incidence of dementia: A Danish Nurse Cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Declining incidence of dementia: A national registry-based study over 20 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ceramides and phospholipids are downregulated with liraglutide treatment: results from the LiraFlame randomized controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Liu Shi
  • Sarah Westwood
  • Alison L Baird
  • Laura Winchester
  • Valerija Dobricic
  • Fabian Kilpert
  • Shengjun Hong
  • Andre Franke
  • Abdul Hye
  • Nicholas J Ashton
  • Angharad R Morgan
  • Isabelle Bos
  • Stephanie J B Vos
  • Noel J Buckley
  • Mara Ten Kate
  • Philip Scheltens
  • Rik Vandenberghe
  • Silvy Gabel
  • Karen Meersmans
  • Sebastiaan Engelborghs
  • Ellen E De Roeck
  • Kristel Sleegers
  • Giovanni B Frisoni
  • Olivier Blin
  • Jill C Richardson
  • Régis Bordet
  • José L Molinuevo
  • Lorena Rami
  • Anders Wallin
  • Petronella Kettunen
  • Magda Tsolaki
  • Frans Verhey
  • Alberto Lleó
  • Daniel Alcolea
  • Julius Popp
  • Gwendoline Peyratout
  • Pablo Martinez-Lage
  • Mikel Tainta
  • Peter Johannsen
  • Charlotte E Teunissen
  • Yvonne Freund-Levi
  • Lutz Frölich
  • Cristina Legido-Quigley
  • Frederik Barkhof
  • Kaj Blennow
  • Henrik Zetterberg
  • Susan Baker
  • B Paul Morgan
  • Johannes Streffer
  • Pieter Jelle Visser
  • Lars Bertram
  • Simon Lovestone
  • Alejo J Nevado-Holgado
Vis graf over relationer

INTRODUCTION: Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.

METHODS: 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.

RESULTS: A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve = 0.78) and the replication group (area under the curve = 0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization.

DISCUSSION: The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.

OriginalsprogEngelsk
TidsskriftAlzheimer's & dementia : the journal of the Alzheimer's Association
Vol/bind15
Udgave nummer11
Sider (fra-til)1478-1488
Antal sider11
ISSN1552-5260
DOI
StatusUdgivet - nov. 2019

Bibliografisk note

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

ID: 57975462