Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Discovering correlates of age-related decline in a healthy late-midlife male birth cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Mucosal microRNAs relate to age and severity of disease in ulcerative colitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Occult cardiac amyloidosis?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Discovering markers of healthy aging: a prospective study in a Danish male birth cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Effects of methylphenidate on sensory and sensorimotor gating of initially psychostimulant-naïve adult ADHD patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Brain capillary pericytes and neurovascular coupling

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Studies exploring age-related brain and cognitive change have identified substantial heterogeneity among individuals, but the underlying reasons for the differential trajectories remain largely unknown. We investigated cross-sectional and longitudinal associations between brain-imaging phenotypes (IDPs) and cognitive ability, and how these relations may be modified by common risk and protective factors. Participants were recruited from the 1953 Danish Male Birth Cohort (N=123), a longitudinal study of cognitive and brain ageing. Childhood IQ and socio-demographic factors are available for these participants who have been assessed regularly on multiple IDPs and behavioural factors in midlife. Using Pearson correlations and canonical correlation analysis (CCA), we explored the relation between 454 IDPs and 114 behavioural variables. CCA identified a single mode of population covariation coupling cross-subject longitudinal changes in brain structure to changes in cognitive performance and to a range of age-related covariates (r=0.92, Pcorrected < 0.001). Specifically, this CCA-mode indicated that; decreases in IQ and speed assessed tasks, higher rates of familial myocardial infarct, less physical activity, and poorer mental health are associated with larger decreases in whole brain grey matter and white matter. We found no evidence supporting the role of baseline scores as predictors of impending brain and behavioural change in late-midlife.

OriginalsprogEngelsk
TidsskriftAging
Vol/bind12
Udgave nummer17
Sider (fra-til)16709-16743
Antal sider35
ISSN1945-4589
DOI
StatusUdgivet - 10 sep. 2020

ID: 61735851