Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Discordance Between Glucose Levels Measured in Interstitial Fluid vs in Venous Plasma After Oral Glucose Administration: A Post-Hoc Analysis From the Randomised Controlled PRE-D Trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Editorial: Proglucagon-Derived Peptides

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Prevalence of Pathogenic Germline DICER1 Variants in Young Individuals Thyroidectomised Due to Goitre - A National Danish Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  3. Impact of meal type on gastrointestinal transit and hormonal response: A randomized crossover study

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Vis graf over relationer

Aims: The oral glucose tolerance test (OGTT) is together with haemoglobin A1c (HbA1c) gold standard for diagnosing prediabetes and diabetes. The objective of this study was to assess the concordance between glucose values obtained from venous plasma versus interstitial fluid after oral glucose administration in 120 individuals with prediabetes and overweight/obesity.

Methods: 120 adults with prediabetes defined by HbA1c 39-47 mmol/mol and overweight or obesity who participated in the randomised controlled PRE-D trial were included in the study. Venous plasma glucose concentrations were measured at 0, 30, 60 and 120 minutes during a 75 g oral glucose tolerance test (OGTT) performed on three different occasions within a 26 weeks period. During the OGTT, the participants wore a CGM device (IPro2, Medtronic), which assessed glucose concentrations every five minutes.

Results: A total of 306 OGTTs with simultaneous CGM measurements were obtained. Except in fasting, the CGM glucose values were below the OGTT values throughout the OGTT period with mean (SD) differences of 0.2 (0.7) mmol/L at time 0 min, -1.1 (1.3) at 30 min, -1.4 (1.8) at 60 min, and -0.5 (1.1) at 120 min). For measurements at 0 and 120 min, there was a proportional bias with an increasing mean difference between CGM and OGTT values with increasing mean of the two measurements.

Conclusions: Due to poor agreement between the OGTT and CGM with wide 95% limits of agreement and proportional bias at 0 and 120 min, the potential for assessing glucose tolerance in prediabetes using CGM is questionable.

TidsskriftFrontiers in Endocrinology
StatusUdgivet - 5 okt. 2021

Bibliografisk note

Funding Information:
The study was funded by the Novo Nordisk Foundation, AstraZeneca AB, the Danish Innovation Foundation, and University of Copenhagen. The funders had no role in study design, data collection, data analysis, interpretation, or writing of the report. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication.

Publisher Copyright:
© Copyright © 2021 Færch, Amadid, Bruhn, Clemmensen, Hulman, Ried-Larsen, Blond, Jørgensen and Vistisen.

ID: 69007539