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Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

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Spedden, Meaghan Elizabeth ; Beck, Mikkel Malling ; Christensen, Mark Schram ; Dietz, Martin Jensen ; Karabanov, Anke Ninija ; Geertsen, Svend Sparre ; Nielsen, Jens Bo ; Lundbye-Jensen, Jesper. / Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults. I: NeuroImage. 2020 ; Bind 218.

Bibtex

@article{ff193d0d1127471180a85348c912cd67,
title = "Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults",
abstract = "The control of ankle muscle force is an integral component of walking and postural control. Aging impairs the ability to produce force steadily and accurately, which can compromise functional capacity and quality of life. Here, we hypothesized that reduced force control in older adults would be associated with altered cortico-cortical communication within a network comprising the primary motor area (M1), the premotor cortex (PMC), parietal, and prefrontal regions. We examined electroencephalographic (EEG) responses from fifteen younger (20-26 yr) and fifteen older (65-73 yr) participants during a unilateral dorsiflexion force-tracing task. Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB) were used to investigate how directed connectivity between contralateral M1, PMC, parietal, and prefrontal regions was related to age group and precision in force production. DCM and PEB analyses revealed that the strength of connections between PMC and M1 were related to ankle force precision and differed by age group. For young adults, bidirectional PMC-M1 coupling was negatively related to task performance: stronger backward M1-PMC and forward PMC-M1 coupling was associated with worse force precision. The older group exhibited deviations from this pattern. For the PMC to M1 coupling, there were no age-group differences in coupling strength; however, within the older group, stronger coupling was associated with better performance. For the M1 to PMC coupling, older adults followed the same pattern as young adults - with stronger coupling accompanied by worse performance - but coupling strength was lower than in the young group. Our results suggest that bidirectional M1-PMC communication is related to precision in ankle force production and that this relationship changes with aging. We argue that the observed differences reflect compensatory reorganization that counteracts age-related sensorimotor declines and contributes to maintaining performance.",
keywords = "Aging, Connectivity, DCM, EEG",
author = "Spedden, {Meaghan Elizabeth} and Beck, {Mikkel Malling} and Christensen, {Mark Schram} and Dietz, {Martin Jensen} and Karabanov, {Anke Ninija} and Geertsen, {Svend Sparre} and Nielsen, {Jens Bo} and Jesper Lundbye-Jensen",
note = "Copyright {\circledC} 2020 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = "9",
day = "1",
doi = "10.1016/j.neuroimage.2020.116982",
language = "English",
volume = "218",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

AU - Spedden, Meaghan Elizabeth

AU - Beck, Mikkel Malling

AU - Christensen, Mark Schram

AU - Dietz, Martin Jensen

AU - Karabanov, Anke Ninija

AU - Geertsen, Svend Sparre

AU - Nielsen, Jens Bo

AU - Lundbye-Jensen, Jesper

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - The control of ankle muscle force is an integral component of walking and postural control. Aging impairs the ability to produce force steadily and accurately, which can compromise functional capacity and quality of life. Here, we hypothesized that reduced force control in older adults would be associated with altered cortico-cortical communication within a network comprising the primary motor area (M1), the premotor cortex (PMC), parietal, and prefrontal regions. We examined electroencephalographic (EEG) responses from fifteen younger (20-26 yr) and fifteen older (65-73 yr) participants during a unilateral dorsiflexion force-tracing task. Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB) were used to investigate how directed connectivity between contralateral M1, PMC, parietal, and prefrontal regions was related to age group and precision in force production. DCM and PEB analyses revealed that the strength of connections between PMC and M1 were related to ankle force precision and differed by age group. For young adults, bidirectional PMC-M1 coupling was negatively related to task performance: stronger backward M1-PMC and forward PMC-M1 coupling was associated with worse force precision. The older group exhibited deviations from this pattern. For the PMC to M1 coupling, there were no age-group differences in coupling strength; however, within the older group, stronger coupling was associated with better performance. For the M1 to PMC coupling, older adults followed the same pattern as young adults - with stronger coupling accompanied by worse performance - but coupling strength was lower than in the young group. Our results suggest that bidirectional M1-PMC communication is related to precision in ankle force production and that this relationship changes with aging. We argue that the observed differences reflect compensatory reorganization that counteracts age-related sensorimotor declines and contributes to maintaining performance.

AB - The control of ankle muscle force is an integral component of walking and postural control. Aging impairs the ability to produce force steadily and accurately, which can compromise functional capacity and quality of life. Here, we hypothesized that reduced force control in older adults would be associated with altered cortico-cortical communication within a network comprising the primary motor area (M1), the premotor cortex (PMC), parietal, and prefrontal regions. We examined electroencephalographic (EEG) responses from fifteen younger (20-26 yr) and fifteen older (65-73 yr) participants during a unilateral dorsiflexion force-tracing task. Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB) were used to investigate how directed connectivity between contralateral M1, PMC, parietal, and prefrontal regions was related to age group and precision in force production. DCM and PEB analyses revealed that the strength of connections between PMC and M1 were related to ankle force precision and differed by age group. For young adults, bidirectional PMC-M1 coupling was negatively related to task performance: stronger backward M1-PMC and forward PMC-M1 coupling was associated with worse force precision. The older group exhibited deviations from this pattern. For the PMC to M1 coupling, there were no age-group differences in coupling strength; however, within the older group, stronger coupling was associated with better performance. For the M1 to PMC coupling, older adults followed the same pattern as young adults - with stronger coupling accompanied by worse performance - but coupling strength was lower than in the young group. Our results suggest that bidirectional M1-PMC communication is related to precision in ankle force production and that this relationship changes with aging. We argue that the observed differences reflect compensatory reorganization that counteracts age-related sensorimotor declines and contributes to maintaining performance.

KW - Aging

KW - Connectivity

KW - DCM

KW - EEG

UR - http://www.scopus.com/inward/record.url?scp=85085945125&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2020.116982

DO - 10.1016/j.neuroimage.2020.116982

M3 - Journal article

VL - 218

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116982

ER -

ID: 59931933