Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg

Mads Buhl, Ermina Bosnjak, Mikkel H Vendelbo, Jakob Gjedsted, Roni R Nielsen, Thomas K-Hafstrøm, Esben T Vestergaard, Niels Jessen, Else Tønnesen, Andreas B Møller, Steen B Pedersen, Henriette Pilegaard, Rasmus S Biensø, Jens O L Jørgensen, Niels Møller

    18 Citationer (Scopus)

    Abstract

    Accumulating evidence suggests that chronic exposure to lipopolysaccharide (LPS, endotoxin) may create a constant low-grade inflammation, leading to insulin resistance and diabetes. All previous human studies assessing the metabolic actions of LPS have used systemic administration, making discrimination between direct and indirect effects impossible.
    OriginalsprogEngelsk
    TidsskriftThe Journal of clinical endocrinology and metabolism
    Vol/bind98
    Udgave nummer5
    Sider (fra-til)2090-9
    Antal sider10
    ISSN0021-972X
    DOI
    StatusUdgivet - maj 2013

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