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Direct action of endocrine disrupting chemicals on human sperm

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Harvard

Schiffer, C, Müller, A, Egeberg, DL, Alvarez, L, Brenker, C, Rehfeld, A, Frederiksen, H, Wäschle, B, Kaupp, UB, Balbach, M, Wachten, D, Skakkebaek, NE, Almstrup, K & Strünker, T 2014, 'Direct action of endocrine disrupting chemicals on human sperm' E M B O Reports, bind 15, s. 758-65. https://doi.org/10.15252/embr.201438869

APA

CBE

Schiffer C, Müller A, Egeberg DL, Alvarez L, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T. 2014. Direct action of endocrine disrupting chemicals on human sperm. E M B O Reports. 15:758-65. https://doi.org/10.15252/embr.201438869

MLA

Vancouver

Author

Schiffer, Christian ; Müller, Astrid ; Egeberg, Dorte L ; Alvarez, Luis ; Brenker, Christoph ; Rehfeld, Anders ; Frederiksen, Hanne ; Wäschle, Benjamin ; Kaupp, U Benjamin ; Balbach, Melanie ; Wachten, Dagmar ; Skakkebaek, Niels E ; Almstrup, Kristian ; Strünker, Timo. / Direct action of endocrine disrupting chemicals on human sperm. I: E M B O Reports. 2014 ; Bind 15. s. 758-65.

Bibtex

@article{0c3edca44d184f40afaf05c4a65d4afc,
title = "Direct action of endocrine disrupting chemicals on human sperm",
abstract = "Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.",
author = "Christian Schiffer and Astrid M{\"u}ller and Egeberg, {Dorte L} and Luis Alvarez and Christoph Brenker and Anders Rehfeld and Hanne Frederiksen and Benjamin W{\"a}schle and Kaupp, {U Benjamin} and Melanie Balbach and Dagmar Wachten and Skakkebaek, {Niels E} and Kristian Almstrup and Timo Str{\"u}nker",
year = "2014",
month = "5",
day = "12",
doi = "10.15252/embr.201438869",
language = "English",
volume = "15",
pages = "758--65",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Direct action of endocrine disrupting chemicals on human sperm

AU - Schiffer, Christian

AU - Müller, Astrid

AU - Egeberg, Dorte L

AU - Alvarez, Luis

AU - Brenker, Christoph

AU - Rehfeld, Anders

AU - Frederiksen, Hanne

AU - Wäschle, Benjamin

AU - Kaupp, U Benjamin

AU - Balbach, Melanie

AU - Wachten, Dagmar

AU - Skakkebaek, Niels E

AU - Almstrup, Kristian

AU - Strünker, Timo

PY - 2014/5/12

Y1 - 2014/5/12

N2 - Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

AB - Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

U2 - 10.15252/embr.201438869

DO - 10.15252/embr.201438869

M3 - Journal article

VL - 15

SP - 758

EP - 765

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

ER -

ID: 44291060