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Region Hovedstaden - en del af Københavns Universitetshospital
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Direct action of endocrine disrupting chemicals on human sperm

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Vis graf over relationer

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

OriginalsprogEngelsk
TidsskriftE M B O Reports
Vol/bind15
Sider (fra-til)758-65
ISSN1469-221X
DOI
StatusUdgivet - 12 maj 2014

ID: 44291060