Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

Keyphrases

• Bone Resorption 100%
• Acidification 100%
• Resorption Lacunae 100%
• Osteoclastic Bone Resorption 100%
• Diphyllin 100%
• V-ATPase Inhibitor 100%
• Vacuolar H+-ATPase (V-ATPase) 50%
• Osteoclast 42%
• Human Osteoblasts 28%
• ClC-7 21%
• Osteoclastic 21%
• Natural Compounds 21%
• Lysosomal Acidification 21%
• CTX-I 14%
• IC50 14%
• Cell Viability 14%
• TRAcP 14%
• Resorption 14%
• Pit Area 14%
• Bafilomycin A1 14%
• Novel Treatments 7%
• Abrogation 7%
• Granulocyte Colony-stimulating Factor (G-CSF) 7%
• Bone Formation 7%
• Pharmacological Effects 7%
• Supernatant 7%
• Calcium Release 7%
• Chloride Channel 7%
• Bone Metabolic Disorder 7%
• C-terminal Telopeptide of Type I Collagen 7%
• CD14+ Monocytes 7%
• IC50 Value 7%
• Nodule Formation 7%
• Bone Nodule 7%
• Bone Disorders 7%
• Novel Inhibitors 7%
• Acridine Orange 7%
• Osteoblast Cell Line 7%
• MC3T3-E1 7%
• Chromaffin Granules 7%
• Mouse Osteoblasts 7%
• ATPase Assay 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine Triphosphatase Inhibitor 100%
• Diprophylline 100%
• Adenosine Triphosphatase 50%
• Natural Product 21%
• IC50 21%
• Cell Viability 14%
• Bafilomycin A1 14%
• Mouse 7%
• Metabolic Disorder 7%
• Bone Disease 7%
• Chloride Channel 7%
• Collagen Type 1 7%
• Osteoclast Differentiation Factor 7%
• Telopeptide 7%
• Acridine Orange 7%
• Colony Stimulating Factor 1 7%