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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Diminished concentrations of insulin-like growth factor I in cystic fibrosis

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  1. Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome

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  2. The insulin-like growth factor axis and collagen turnover during prednisolone treatment

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  1. Long-term testosterone undecanoate treatment in the elderly testosterone deficient male - an observational cohort study

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  2. Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study

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  3. Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men

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  4. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis

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Vis graf over relationer
Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p <0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.
OriginalsprogEngelsk
TidsskriftArchives of Disease in Childhood. Education and Practice Edition
Vol/bind72
Udgave nummer6
Sider (fra-til)494-7
Antal sider4
ISSN1743-0585
StatusUdgivet - 1995

ID: 36944690