Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors

Yi-Ping Li; Santseharay Ramirez; Daryl Humes; Sanne Brun Jensen; Judith M Gottwein; Jens Bukh

doi:10.1053/j.gastro.2013.11.009

Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors

Yi-Ping Li, Santseharay Ramirez, Daryl Humes, Sanne Brun Jensen, Judith M Gottwein, Jens Bukh

58 Citationer (Scopus)

Abstract

Hepatitis C virus (HCV) therapy will benefit from the preclinical evaluation of direct-acting antiviral (DAA) agents in infectious culture systems that test the effects on different virus genotypes. We developed HCV recombinants comprising the 5'UTR-NS5A (5-5A) from genotypes 1-6 and 2a(JFH1) NS5B-3'UTR, and tested the effects of NS3 protease and NS5A inhibitors on these recombinants.

Originalsprog	Engelsk
Tidsskrift	Gastroenterology
Vol/bind	146
Udgave nummer	3
Sider (fra-til)	812-821
Antal sider	10
ISSN	0016-5085
DOI	https://doi.org/10.1053/j.gastro.2013.11.009
Status	Udgivet - mar. 2014

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10.1053/j.gastro.2013.11.009

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title = "Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors",

abstract = "Hepatitis C virus (HCV) therapy will benefit from the preclinical evaluation of direct-acting antiviral (DAA) agents in infectious culture systems that test the effects on different virus genotypes. We developed HCV recombinants comprising the 5'UTR-NS5A (5-5A) from genotypes 1-6 and 2a(JFH1) NS5B-3'UTR, and tested the effects of NS3 protease and NS5A inhibitors on these recombinants.",

author = "Yi-Ping Li and Santseharay Ramirez and Daryl Humes and {Brun Jensen}, Sanne and Gottwein, {Judith M} and Jens Bukh",

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AU - Li, Yi-Ping

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AU - Brun Jensen, Sanne

AU - Gottwein, Judith M

AU - Bukh, Jens

PY - 2014/3

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N2 - Hepatitis C virus (HCV) therapy will benefit from the preclinical evaluation of direct-acting antiviral (DAA) agents in infectious culture systems that test the effects on different virus genotypes. We developed HCV recombinants comprising the 5'UTR-NS5A (5-5A) from genotypes 1-6 and 2a(JFH1) NS5B-3'UTR, and tested the effects of NS3 protease and NS5A inhibitors on these recombinants.

AB - Hepatitis C virus (HCV) therapy will benefit from the preclinical evaluation of direct-acting antiviral (DAA) agents in infectious culture systems that test the effects on different virus genotypes. We developed HCV recombinants comprising the 5'UTR-NS5A (5-5A) from genotypes 1-6 and 2a(JFH1) NS5B-3'UTR, and tested the effects of NS3 protease and NS5A inhibitors on these recombinants.

U2 - 10.1053/j.gastro.2013.11.009

DO - 10.1053/j.gastro.2013.11.009

M3 - Journal article

C2 - 24262279

SN - 0016-5085

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JO - Gastroenterology

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ER -

Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors

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