Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B

Thilde Nordmann Winther; Claus Heiner Bang-Berthelsen; Ida Louise Heiberg; Flemming Pociot; Birthe Hogh

doi:10.1371/journal.pone.0058236

Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B

Thilde Nordmann Winther, Claus Heiner Bang-Berthelsen, Ida Louise Heiberg, Flemming Pociot, Birthe Hogh

Børne- og Ungeafdelingen

48 Citationer (Scopus)

Abstract

Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected with HBV may provide insight into the pathogenesis of CHB and lead to advances in the management of children with CHB.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	3
Sider (fra-til)	e58236
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0058236
Status	Udgivet - 2013

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10.1371/journal.pone.0058236

Citationsformater

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title = "Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B",

abstract = "Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected with HBV may provide insight into the pathogenesis of CHB and lead to advances in the management of children with CHB.",

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T1 - Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B

AU - Winther, Thilde Nordmann

AU - Bang-Berthelsen, Claus Heiner

AU - Heiberg, Ida Louise

AU - Pociot, Flemming

AU - Hogh, Birthe

PY - 2013

Y1 - 2013

N2 - Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected with HBV may provide insight into the pathogenesis of CHB and lead to advances in the management of children with CHB.

AB - Children chronically infected with hepatitis B virus (HBV) are at high risk of progressive liver disease. However, no treatment is available that is consistently effective in curing chronic hepatitis B (CHB) in children. Improved understanding of the natural course of disease is warranted. Identification of specific microRNA (miRNA) profiles in children chronically infected with HBV may provide insight into the pathogenesis of CHB and lead to advances in the management of children with CHB.

U2 - 10.1371/journal.pone.0058236

DO - 10.1371/journal.pone.0058236

M3 - Journal article

C2 - 23469271

SN - 1932-6203

VL - 8

SP - e58236

JO - P L o S One

JF - P L o S One

IS - 3

ER -

Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B

Abstract

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