@article{2185010ff748450bb4133a4bb24f5423,
title = "Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum",
abstract = "Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.",
keywords = "Adolescent, Adult, Aged, Animals, Antibodies, Protozoan/biosynthesis, Child, Child, Preschool, Humans, Immunoglobulin G/biosynthesis, Infant, Merozoite Surface Protein 1/immunology, Middle Aged, Peptide Fragments/immunology, Plasmodium falciparum/immunology",
author = "Cavanagh, {D R} and C Doba{\~n}o and Elhassan, {I M} and K Marsh and A Elhassan and L Hviid and Khalil, {E A} and Theander, {T G} and Arnot, {D E} and McBride, {J S}",
year = "2001",
month = feb,
doi = "10.1128/IAI.69.2.1207-1211.2001",
language = "English",
volume = "69",
pages = "1207--11",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",
}