Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

T Edholm; M Degerblad; P Grybäck; Linda Maria Hilsted; Jens Møller Holst; H Jacobsson; S Efendic; P T Schmidt; P M Hellström

doi:10.1111/j.1365-2982.2010.01554.x

Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

T Edholm, M Degerblad, P Grybäck, Linda Maria Hilsted, Jens Møller Holst, H Jacobsson, S Efendic, P T Schmidt, P M Hellström

Afdeling for Klinisk Biokemi DIA

149 Citationer (Scopus)

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins with important effects on glucoregulatory functions. The aim of this study was to investigate effects of GIP and GLP-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans.

Originalsprog	Engelsk
Tidsskrift	Neurogastroenterology and Motility
Vol/bind	22
Udgave nummer	11
Sider (fra-til)	1191-200, e315
ISSN	1350-1925
DOI	https://doi.org/10.1111/j.1365-2982.2010.01554.x
Status	Udgivet - 1 nov. 2010

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AU - Edholm, T

AU - Degerblad, M

AU - Grybäck, P

AU - Hilsted, Linda Maria

AU - Holst, Jens Møller

AU - Jacobsson, H

AU - Efendic, S

AU - Schmidt, P T

AU - Hellström, P M

PY - 2010/11/1

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N2 - Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins with important effects on glucoregulatory functions. The aim of this study was to investigate effects of GIP and GLP-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans.

AB - Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins with important effects on glucoregulatory functions. The aim of this study was to investigate effects of GIP and GLP-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans.

UR - https://www.scopus.com/pages/publications/78649388633

U2 - 10.1111/j.1365-2982.2010.01554.x

DO - 10.1111/j.1365-2982.2010.01554.x

M3 - Journal article

C2 - 20584260

SN - 1350-1925

VL - 22

SP - 1191-200, e315

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

IS - 11

ER -

Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

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