Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

John O Hwabejire; Ayesha M Imam; Guang Jin; Baoling Liu; Yongqing Li; Martin Sillesen; Cecilie H Jepsen; Jennifer Lu; Marc A Demoya; Hasan B Alam

doi:10.1097/TA.0b013e31829a021a

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

John O Hwabejire, Ayesha M Imam, Guang Jin, Baoling Liu, Yongqing Li, Martin Sillesen, Cecilie H Jepsen, Jennifer Lu, Marc A Demoya, Hasan B Alam

Afdeling for Bedøvelse, Operation og TraumeCenter

22 Citationer (Scopus)

Abstrakt

We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.

Originalsprog	Engelsk
Tidsskrift	The journal of trauma and acute care surgery
Vol/bind	75
Udgave nummer	6
Sider (fra-til)	968-75
Antal sider	8
DOI	https://doi.org/10.1097/TA.0b013e31829a021a
Status	Udgivet - dec. 2013

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10.1097/TA.0b013e31829a021a

Citationsformater

Hwabejire, J. O., Imam, A. M., Jin, G., Liu, B., Li, Y., Sillesen, M., Jepsen, C. H., Lu, J., Demoya, M. A., & Alam, H. B. (2013). Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. The journal of trauma and acute care surgery, 75(6), 968-75. https://doi.org/10.1097/TA.0b013e31829a021a

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. / Hwabejire, John O; Imam, Ayesha M; Jin, Guang et al.

I: The journal of trauma and acute care surgery, Bind 75, Nr. 6, 12.2013, s. 968-75.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hwabejire, JO, Imam, AM, Jin, G, Liu, B, Li, Y, Sillesen, M, Jepsen, CH, Lu, J, Demoya, MA & Alam, HB 2013, 'Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury', The journal of trauma and acute care surgery, bind 75, nr. 6, s. 968-75. https://doi.org/10.1097/TA.0b013e31829a021a

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abstract = "We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.",

author = "Hwabejire, {John O} and Imam, {Ayesha M} and Guang Jin and Baoling Liu and Yongqing Li and Martin Sillesen and Jepsen, {Cecilie H} and Jennifer Lu and Demoya, {Marc A} and Alam, {Hasan B}",

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AU - Hwabejire, John O

AU - Imam, Ayesha M

AU - Jin, Guang

AU - Liu, Baoling

AU - Li, Yongqing

AU - Sillesen, Martin

AU - Jepsen, Cecilie H

AU - Lu, Jennifer

AU - Demoya, Marc A

AU - Alam, Hasan B

PY - 2013/12

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N2 - We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.

AB - We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.

U2 - 10.1097/TA.0b013e31829a021a

DO - 10.1097/TA.0b013e31829a021a

M3 - Journal article

C2 - 24256668

VL - 75

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EP - 975

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 6

ER -

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

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