TY - JOUR
T1 - Different risk factor profiles for mucinous and nonmucinous ovarian cancer
T2 - results from the Danish MALOVA study
AU - Soegaard, Marie
AU - Jensen, Allan
AU - Høgdall, Estrid
AU - Christensen, Lise
AU - Høgdall, Claus
AU - Blaakaer, Jan
AU - Kjaer, Susanne K
PY - 2007/6
Y1 - 2007/6
N2 - OBJECTIVES: The aim of the study was to examine the overall risk factors for epithelial ovarian cancer and according to histologic subtypes.MATERIALS AND METHODS: Ovarian cancer cases and controls were recruited from 1995 to 1999, and personal interviews were conducted. A total of 554 cases and 1,564 randomly selected controls were included. The analyses were done using multiple logistic regression models.RESULTS: The overall risk of ovarian cancer decreased with ever being pregnant [odds ratios (OR), 0.40; 95% confidence intervals (CI), 0.30-0.55], with increasing pregnancies (OR, 0.63; 95% CI, 0.45-0.87 and OR, 0.51; 95% CI, 0.37-0.69 for two and three pregnancies as compared with one), and with older age at first and last pregnancy, respectively. Increasing years of ovulation was a very strong risk factor with a 7% to 8% increase in risk for each year of ovulation. Use of oral contraceptives (OR, 0.67, 95% CI, 0.53-0.85) and longer duration of use were associated with a decreased risk of ovarian cancer. Ever use of hormone replacement therapy increased the overall risk (OR, 1.30; 95% CI, 1.05-1.61). For all those variables, the effect was present for serous tumors, endometrioid tumors, and tumors of other histologies, but not for mucinous tumors. In contrast, current smoking was a risk factor only for mucinous tumors (OR, 1.78; 95% CI, 1.01-3.15) and increasing body mass index tended to increase the risk especially for mucinous and endometrioid tumors.CONCLUSIONS: We confirmed already known risk factors for ovarian cancer, and we observed significant differences in the risk profiles between mucinous and nonmucinous tumors indicating different etiologies.
AB - OBJECTIVES: The aim of the study was to examine the overall risk factors for epithelial ovarian cancer and according to histologic subtypes.MATERIALS AND METHODS: Ovarian cancer cases and controls were recruited from 1995 to 1999, and personal interviews were conducted. A total of 554 cases and 1,564 randomly selected controls were included. The analyses were done using multiple logistic regression models.RESULTS: The overall risk of ovarian cancer decreased with ever being pregnant [odds ratios (OR), 0.40; 95% confidence intervals (CI), 0.30-0.55], with increasing pregnancies (OR, 0.63; 95% CI, 0.45-0.87 and OR, 0.51; 95% CI, 0.37-0.69 for two and three pregnancies as compared with one), and with older age at first and last pregnancy, respectively. Increasing years of ovulation was a very strong risk factor with a 7% to 8% increase in risk for each year of ovulation. Use of oral contraceptives (OR, 0.67, 95% CI, 0.53-0.85) and longer duration of use were associated with a decreased risk of ovarian cancer. Ever use of hormone replacement therapy increased the overall risk (OR, 1.30; 95% CI, 1.05-1.61). For all those variables, the effect was present for serous tumors, endometrioid tumors, and tumors of other histologies, but not for mucinous tumors. In contrast, current smoking was a risk factor only for mucinous tumors (OR, 1.78; 95% CI, 1.01-3.15) and increasing body mass index tended to increase the risk especially for mucinous and endometrioid tumors.CONCLUSIONS: We confirmed already known risk factors for ovarian cancer, and we observed significant differences in the risk profiles between mucinous and nonmucinous tumors indicating different etiologies.
KW - Adenocarcinoma/epidemiology
KW - Adenocarcinoma, Mucinous/epidemiology
KW - Adult
KW - Age Factors
KW - Aged
KW - Body Mass Index
KW - Case-Control Studies
KW - Contraceptives, Oral/adverse effects
KW - Female
KW - Humans
KW - Middle Aged
KW - Ovarian Neoplasms/epidemiology
KW - Parity
KW - Pregnancy
KW - Risk Factors
KW - Smoking/adverse effects
U2 - 10.1158/1055-9965.EPI-07-0089
DO - 10.1158/1055-9965.EPI-07-0089
M3 - Journal article
C2 - 17548679
SN - 1055-9965
VL - 16
SP - 1160
EP - 1166
JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
IS - 6
ER -