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Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Smartphone-based self-monitoring in bipolar disorder: evaluation of usability and feasibility of two systems

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Internet use by older adults with bipolar disorder: international survey results

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND: Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated.

METHODS: Patients with bipolar disorder type I (n = 53) and type II (n = 31) used a daily smartphone-based self-monitoring system for 9 months. Data in the present reflect 15.975 observations of daily collected smartphone-based data on patient-evaluated mood.

RESULTS: In models adjusted for age, gender, illness duration and psychopharmacological treatment, patients with bipolar disorder type II experienced more mood instability during depression compared with patients with bipolar disorder type I (B: 0.27, 95% CI 0.007; 0.53, p = 0.044), but lower intensity of manic symptoms. Patients with bipolar disorder type II did not experience lower mean mood or higher intensity of depressive symptoms compared with patients with bipolar disorder type I.

CONCLUSIONS: Compared to bipolar disorder type I, patients with bipolar disorder type II had higher mood instability for depression. Clinically it is of importance to identify these inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability measures are warranted. Trial registration NCT02221336.

OriginalsprogEngelsk
TidsskriftInternational Journal of Bipolar Disorders
Vol/bind7
Udgave nummer1
Sider (fra-til)5
ISSN2194-7511
DOI
StatusUdgivet - 1 feb. 2019

ID: 58078033