Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dietary trans-fatty acid intake in relation to cancer risk: a systematic review and meta-analysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Associations between vitamin D status in pregnancy and offspring neurodevelopment: a systematic literature review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical applications of bovine colostrum therapy: a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Is beer consumption related to measures of abdominal and general obesity? A systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Childhood obesity: successes and failures of preventive interventions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Phase angle measured by bioelectrical impedance analysis and the risk of cardiovascular disease among adult Danes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Protein Intake During Infancy and Subsequent Body Mass Index in Early Childhood: Results from the Melbourne InFANT Program

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Loss of height predicts total and cardiovascular mortality: a cohort study of northern European women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

CONTEXT: Apart from ruminant fat, trans-fatty acids are produced during the partial hydrogenation of vegetable oils, (eg, in the production of ultraprocessed foods). Harmful cardiovascular effects of trans-fatty acids are already proven, but the link with cancer risk has not yet been summarized.

OBJECTIVE: A systematic review (following PRISMA guidelines) - including observational studies on the association of trans-fatty acid intake with any cancer risk - was conducted, with no limitations on population types.

DATA SOURCES: The electronic databases PubMed and Embase were searched to identify relevant studies.

DATA EXTRACTION: This systematic review included 46 articles. Quality was assessed via the Newcastle-Ottawa scale. Meta-analyses were conducted if at least 4 articles exploring the same transfat-cancer pairings were found.

DATA ANALYSIS: Nineteen cancer types have been researched in cohort and case-control studies on trans-fatty acids, with breast cancer (n = 17), prostate cancer (n = 11), and colorectal cancer (n = 9) as the most researched. The meta-analyses on total trans-fat showed a significant positive association for prostate cancer (odds ratio [OR] 1.49; 95%CI, 1.13-1.95) and colorectal cancer (OR 1.26; 95%CI, 1.08-1.46) but not for breast cancer (OR 1.12; 95%CI, 0.99-1.26), ovarian cancer (OR 1.10; 95%CI, 0.94-1.28), or non-Hodgkin lymphoma (OR 1.32; 95%CI, 0.99-1.76). Results were dependent on the fatty acid subtype, with even cancer-protective associations for some partially hydrogenated vegetable oils. Enhancing moderators in the positive transfat-cancer relation were gender (direction was cancer-site specific), European ancestry, menopause, older age, and overweight.

CONCLUSION: Despite heterogeneity, higher risk of prostate and colorectal cancer by high consumption of trans-fatty acids was found. Future studies need methodological improvements (eg, using long-term follow-up cancer data and intake biomarkers). Owing to the lack of studies testing trans-fatty acid subtypes in standardized ways, it is not clear which subtypes (eg, ruminant sources) are more carcinogenic.

SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42018105899.

OriginalsprogEngelsk
TidsskriftNutrition Reviews
Vol/bind79
Udgave nummer7
Sider (fra-til)758-776
Antal sider19
ISSN0029-6643
DOI
StatusUdgivet - 4 jun. 2021

ID: 67547740