Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Memory T helper cells identify patients with nickel, cobalt, and chromium metal allergy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of Anabolic-Androgenic Steroid Abuse on the Contact Activation System

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

SCOPE: To examine potentially immunomodulating effects of dietary benzoxazinoids (BXs), present in cereal grains.

METHODS AND RESULTS: Nineteen healthy volunteers were randomly distributed into two groups, who received diets with high or low content of BXs for 3 wk. After a week's wash-out, the groups switched diets. Peripheral blood mononuclear cells (PBMCs) were stimulated with Porphyromonas gingivalis, Escherichia coli lipopolysaccharide (LPS), or tetanus toxoid (TT). PBMCs from a healthy donor received the same stimuli in presence of serum from each participant receiving BXs. The production of monokines, T-cell cytokines and T-helper cell proliferation were assessed. A 3-wk diet with high BX content enhanced IL-1β responses against LPS and P. gingivalis, as well as TNF-α response against P. gingivalis, after 24 h of stimulation. Moreover, IL-6 was found to be increased after 7 days of stimulation with LPS. No effect was observed on T-cell cytokines or proliferation. BX levels in serum after a single meal did not modify cytokine responses.

CONCLUSION: High dietary intake of BXs enhances bacteria-induced production of pro-inflammatory monokines by PBMCs, but not T-cell responses; presumably due to intrinsic changes within PBMCs, built up over 3 wk of BX-rich diet, rather than to an immediate effects of BXs contained in serum.

OriginalsprogEngelsk
TidsskriftMolecular Nutrition & Food Research
Vol/bind59
Udgave nummer11
Sider (fra-til)2190-8
Antal sider9
ISSN1613-4125
DOI
StatusUdgivet - nov. 2015

ID: 46216532