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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dientamoeba fragilis - a Commensal in Children in Danish Day Care Centers

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Vis graf over relationer

Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0-6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009-2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 (68.3%) of 142 children. We evaluated associations between seven plausible risk factors (age, gender, having siblings, having domestic animals at home, having had infant colic, recent history of intake of antibiotics, and recent history of travel abroad) as well as six reported symptoms (lack of appetite, nausea, vomiting, abdominal pain, weight loss, and diarrhea) and testing positive for D. fragilis The final multivariable model identified being >3 years old and having a history of recent traveling abroad as risk factors for testing positive for D. fragilis Moreover, univariable analyses indicated that having siblings was a risk factor. There was no statistical association between a recent history of gastrointestinal symptoms and testing positive for D. fragilis Among the 108 children who were represented by ≥ 2 samples and thus included in the longitudinal analysis, 32 tested negative on first sample and positive later, and the last sample from each of the 108 children was positive. The results are in support of D. fragilis being a common enteric commensal in this population.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Microbiology
Vol/bind55
Udgave nummer6
Sider (fra-til)1707-1713
ISSN0095-1137
DOI
StatusUdgivet - 1 jun. 2017

ID: 50138647