Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations

Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Orbital lymphoma

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. A review of nasal, paranasal, and skull base tumors invading the orbit

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Lymphoma of the eyelid

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The association between multiple sclerosis and uveitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Malignant lymphoma of the conjunctiva

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lymphoma of the Lacrimal Gland - An International Multicenter Retrospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ocular adnexal lymphoma in Denmark: a nationwide study of 387 cases from 1980 to 2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

The orbit can harbor mass lesions of various cellular origins. The symptoms vary considerably according to the nature, location, and extent of the disease and include common signs of proptosis, globe displacement, eyelid swelling, and restricted eye motility. Although radiological imaging tools are improving, with each imaging pattern having its own differential diagnosis, orbital mass lesions often pose a diagnostic challenge. To provide an accurate, specific, and sufficiently comprehensive diagnosis, to optimize clinical management and estimate prognosis, pathological examination of a tissue biopsy is essential. Diagnostic orbital tissue biopsy is obtained through a minimally invasive orbitotomy procedure or, in selected cases, fine needle aspiration. The outcome of successful biopsy, however, is centered on its representativeness, processing, and interpretation. Owing to the often small volume of the orbital biopsies, artifacts in the specimens should be limited by careful peroperative tissue handling, fixation, processing, and storage. Some orbital lesions can be characterized on the basis of cytomorphology alone, whereas others need ancillary molecular testing to render the most reliable diagnosis of therapeutic, prognostic, and predictive value. Herein, we review the diagnostic algorithm for orbital mass lesions, using clinical, radiological, and pathological recommendations, and discuss the methods and potential pitfalls in orbital tissue biopsy acquisition and analysis.

OriginalsprogEngelsk
TidsskriftSurvey of Ophthalmology
Vol/bind64
Udgave nummer6
Sider (fra-til)741-756
Antal sider16
ISSN0039-6257
DOI
StatusUdgivet - 6 jul. 2019

Bibliografisk note

Copyright © 2019 Elsevier Inc. All rights reserved.

ID: 58939176