Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Thomas Reinert; Michael Skov Borre; Anders Tendal Christiansen; Gregers G Hermann; Torben Falck Ørntoft; Lars Dyrskjøt

doi:10.1371/journal.pone.0046297

Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Thomas Reinert, Michael Skov Borre, Anders Tendal Christiansen, Gregers G Hermann, Torben Falck Ørntoft, Lars Dyrskjøt

97 Citationer (Scopus)

Abstract

Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	10
Sider (fra-til)	e46297
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0046297
Status	Udgivet - 2012

Adgang til dokumentet

10.1371/journal.pone.0046297

Citationsformater

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title = "Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation",

abstract = "Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.",

author = "Thomas Reinert and Borre, {Michael Skov} and Christiansen, {Anders Tendal} and Hermann, {Gregers G} and {\O}rntoft, {Torben Falck} and Lars Dyrskj{\o}t",

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language = "English",

volume = "7",

pages = "e46297",

journal = "P L o S One",

issn = "1932-6203",

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T1 - Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

AU - Reinert, Thomas

AU - Borre, Michael Skov

AU - Christiansen, Anders Tendal

AU - Hermann, Gregers G

AU - Ørntoft, Torben Falck

AU - Dyrskjøt, Lars

PY - 2012

Y1 - 2012

N2 - Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.

AB - Non muscle invasive bladder cancer (NMIBC) has the highest recurrence rate of any malignancy and as many as 70% of patients experience relapse. Aberrant DNA methylation is present in all bladder tumors and can be detected in urine specimens. Previous studies have identified DNA methylation markers that showed significant diagnostic value. We evaluated the significance of the biomarkers for early detection of tumor recurrence in urine.

U2 - 10.1371/journal.pone.0046297

DO - 10.1371/journal.pone.0046297

M3 - Journal article

C2 - 23056278

SN - 1932-6203

VL - 7

SP - e46297

JO - P L o S One

JF - P L o S One

IS - 10

ER -

Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation

Abstract

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