Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

Matthias M Herth; Valdemar Lykke Andersen; S Lehel; Jacob Madsen; Gitte M Knudsen; Jesper Langgaard Kristensen

doi:10.1039/c3cc41027g

Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

Matthias M Herth, Valdemar Lykke Andersen, S Lehel, Jacob Madsen, Gitte M Knudsen, Jesper Langgaard Kristensen

63 Citationer (Scopus)

Abstract

Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	49
Udgave nummer	36
Sider (fra-til)	3805-7
Antal sider	3
ISSN	1359-7345
DOI	https://doi.org/10.1039/c3cc41027g
Status	Udgivet - 2013

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abstract = "Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.",

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volume = "49",

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TY - JOUR

T1 - Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

AU - Herth, Matthias M

AU - Andersen, Valdemar Lykke

AU - Lehel, S

AU - Madsen, Jacob

AU - Knudsen, Gitte M

AU - Kristensen, Jesper Langgaard

PY - 2013

Y1 - 2013

N2 - Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.

AB - Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.

UR - https://www.scopus.com/pages/publications/84876153172

U2 - 10.1039/c3cc41027g

DO - 10.1039/c3cc41027g

M3 - Journal article

C2 - 23535705

SN - 1359-7345

VL - 49

SP - 3805

EP - 3807

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

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