TY - JOUR
T1 - Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)
AU - Krabbe, Simon
AU - Eshed, Iris
AU - Gandjbakhch, Frédérique
AU - Pedersen, Susanne Juhl
AU - Bird, Paul
AU - Mathew, Ashish J
AU - Lambert, Robert G
AU - Maksymowych, Walter P
AU - Glinatsi, Daniel Erik
AU - Stoenoiu, Maria S
AU - Poggenborg, René Panduro
AU - Jans, Lennart
AU - Jaremko, Jacob L
AU - Herregods, Nele
AU - Foltz, Violaine
AU - Conaghan, Philip G
AU - Althoff, Christian E
AU - Paschke, Joel
AU - Peterfy, Charles
AU - Hermann, Kay-Geert A
AU - Østergaard, Mikkel
AU - for the OMERACT MRI in Arthritis Working Group
N1 - COPECARE
PY - 2019/9
Y1 - 2019/9
N2 - OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis.METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis.RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77.CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
AB - OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis.METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis.RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77.CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
U2 - 10.3899/jrheum.181084
DO - 10.3899/jrheum.181084
M3 - Journal article
C2 - 30770508
SN - 0315-162X
VL - 46
SP - 1215
EP - 1221
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 9
ER -