Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020

Kaitlin A Quinn; Sara Monti; Robin Christensen; David Jayne; Carol A Langford; Georgia E Lanier; Alfred Mahr; Christian Pagnoux; Beverley Shea; Peter Tugwell; Maria Bjork Viðarsdóttir; Gunnar Tomasson; Peter A Merkel

doi:10.1016/j.semarthrit.2021.07.001

Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020

Kaitlin A Quinn, Sara Monti, Robin Christensen, David Jayne, Carol A Langford, Georgia E Lanier, Alfred Mahr, Christian Pagnoux, Beverley Shea, Peter Tugwell, Maria Bjork Viðarsdóttir, Gunnar Tomasson, Peter A Merkel

Parker Instituttet

6 Citationer (Scopus)

Abstract

OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group aims to develop composite response criteria for ANCA-Associated Vasculitis (AAV).

METHODS: The project follows the OMERACT approach for composite measures: (i) choose relevant domains; (ii) define high-quality instruments; (iii) decide on a scoring system approach; (iv) put through the OMERACT Filter 2.1 for validation.

RESULTS: A systematic literature review of outcome measures used in clinical trials in AAV and an international Delphi exercise among patients with AAV and clinician-investigators with expertise in AAV have been completed to inform the candidate domains/instruments for the composite response criteria, which are the first two steps in the OMERACT approach for developing composite measures. Results of the systematic literature review and Delphi were presented at the OMERACT 2020 virtual workshop, and feedback was received on the next steps of the project, including the development of a scoring system approach.

CONCLUSION: The ultimate goal of this project is to develop validated composite response criteria for use in clinical trials of AAV.

Originalsprog	Engelsk
Tidsskrift	Seminars in Arthritis and Rheumatism
Vol/bind	51
Udgave nummer	5
Sider (fra-til)	1134-1138
Antal sider	5
ISSN	0049-0172
DOI	https://doi.org/10.1016/j.semarthrit.2021.07.001
Status	Udgivet - okt. 2021

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Quinn, K. A., Monti, S., Christensen, R., Jayne, D., Langford, C. A., Lanier, G. E., Mahr, A., Pagnoux, C., Shea, B., Tugwell, P., Viðarsdóttir, M. B., Tomasson, G., & Merkel, P. A. (2021). Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020. Seminars in Arthritis and Rheumatism, 51(5), 1134-1138. https://doi.org/10.1016/j.semarthrit.2021.07.001

Quinn, KA, Monti, S, Christensen, R, Jayne, D, Langford, CA, Lanier, GE, Mahr, A, Pagnoux, C, Shea, B, Tugwell, P, Viðarsdóttir, MB, Tomasson, G & Merkel, PA 2021, 'Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020', Seminars in Arthritis and Rheumatism, bind 51, nr. 5, s. 1134-1138. https://doi.org/10.1016/j.semarthrit.2021.07.001

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abstract = "OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group aims to develop composite response criteria for ANCA-Associated Vasculitis (AAV).METHODS: The project follows the OMERACT approach for composite measures: (i) choose relevant domains; (ii) define high-quality instruments; (iii) decide on a scoring system approach; (iv) put through the OMERACT Filter 2.1 for validation.RESULTS: A systematic literature review of outcome measures used in clinical trials in AAV and an international Delphi exercise among patients with AAV and clinician-investigators with expertise in AAV have been completed to inform the candidate domains/instruments for the composite response criteria, which are the first two steps in the OMERACT approach for developing composite measures. Results of the systematic literature review and Delphi were presented at the OMERACT 2020 virtual workshop, and feedback was received on the next steps of the project, including the development of a scoring system approach.CONCLUSION: The ultimate goal of this project is to develop validated composite response criteria for use in clinical trials of AAV.",

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AU - Monti, Sara

AU - Christensen, Robin

AU - Jayne, David

AU - Langford, Carol A

AU - Lanier, Georgia E

AU - Mahr, Alfred

AU - Pagnoux, Christian

AU - Shea, Beverley

AU - Tugwell, Peter

AU - Viðarsdóttir, Maria Bjork

AU - Tomasson, Gunnar

AU - Merkel, Peter A

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AB - OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group aims to develop composite response criteria for ANCA-Associated Vasculitis (AAV).METHODS: The project follows the OMERACT approach for composite measures: (i) choose relevant domains; (ii) define high-quality instruments; (iii) decide on a scoring system approach; (iv) put through the OMERACT Filter 2.1 for validation.RESULTS: A systematic literature review of outcome measures used in clinical trials in AAV and an international Delphi exercise among patients with AAV and clinician-investigators with expertise in AAV have been completed to inform the candidate domains/instruments for the composite response criteria, which are the first two steps in the OMERACT approach for developing composite measures. Results of the systematic literature review and Delphi were presented at the OMERACT 2020 virtual workshop, and feedback was received on the next steps of the project, including the development of a scoring system approach.CONCLUSION: The ultimate goal of this project is to develop validated composite response criteria for use in clinical trials of AAV.

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Developing a composite outcome tool to measure response to treatment in ANCA-associated vasculitis: A mixed methods study from OMERACT 2020

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