Abstract
A relatively simple, sensitive and precise gas chromatographic method for the determination of isradipine, a calcium antagonist of the dihydropyridine type, and its main metabolite in serum is described. Using a one-step extraction procedure, a wide-bore column and a nitrogen-phosphorus detector, a limit of quantitation of 0.5 and 2.0 nM for isradipine and the metabolite was found. No interferences from several drugs were observed. The method was successfully used in a pharmacokinetic study in hypertensive women during pregnancy.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Chromatography |
Vol/bind | 574 |
Udgave nummer | 1 |
Sider (fra-til) | 161-5 |
Antal sider | 5 |
ISSN | 0021-9673 |
DOI | |
Status | Udgivet - 7 feb. 1992 |