Determination of isradipine and its pyridine metabolite in serum by capillary column gas chromatography with nitrogen-selective detection

H R Christensen, H R Angelo, K Skajaa

11 Citationer (Scopus)

Abstract

A relatively simple, sensitive and precise gas chromatographic method for the determination of isradipine, a calcium antagonist of the dihydropyridine type, and its main metabolite in serum is described. Using a one-step extraction procedure, a wide-bore column and a nitrogen-phosphorus detector, a limit of quantitation of 0.5 and 2.0 nM for isradipine and the metabolite was found. No interferences from several drugs were observed. The method was successfully used in a pharmacokinetic study in hypertensive women during pregnancy.

OriginalsprogEngelsk
TidsskriftJournal of Chromatography
Vol/bind574
Udgave nummer1
Sider (fra-til)161-5
Antal sider5
ISSN0021-9673
DOI
StatusUdgivet - 7 feb. 1992

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