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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Determinants of Neurodevelopment in Early Childhood - Results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort

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Vis graf over relationer

AIM: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.

METHODS: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010 ) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birth weights <2500g, resulting in 650 children analyzed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.

RESULTS: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema, and number of sick days (p>0.05 in all tests). Early age at milestone achievement was associated with male sex (p=0.05), lower maternal age (p=0.02), higher gestational age (p<0.001) and paternity leave (p=0.01). A higher 1-year language score was associated with female sex (p=0.02) and maternal smoking during pregnancy (p=0.01) and a higher 2-year language score with female sex (p<0.001) and being first born (p=0.01). A higher cognitive score was associated with female sex (p=0.02).

CONCLUSION: Neurodevelopmental scores were unrelated to breast-feeding, persistent wheeze, eczema, and number of sick days. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa paediatrica
Vol/bind108
Udgave nummer9
Sider (fra-til)1632-1641
Antal sider10
ISSN1651-2227
DOI
StatusUdgivet - sep. 2019

ID: 56581669