Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Determinants of low risk of asthma exacerbation during pregnancy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Advancing the management of Obstructive Airways Diseases through Translational Research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High breast milk IL-1β level is associated with reduced risk of childhood eczema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Assessment of asthma control every 4-6 weeks during pregnancy is recommended to reduce risk of exacerbation, and by that improve outcome.

OBJECTIVE: To identify determinants of pregnancies with low risk of asthma exacerbation.

METHODS: All pregnant women enrolled into the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital since 2007. Assessment of asthma control, adjustment of treatment, spirometry and measurement of exhaled nitric oxide (FE NO) were performed, and baseline characteristics and exacerbation history was collected at enrolment. Determinants of low-exacerbation risk pregnancies were identified by logistic regression analysis (stepwise backward elimination).

RESULTS: In 1,283 pregnancies, 107 exacerbations were observed. Multiple regression analysis revealed that no history of pre-pregnancy exacerbations (p<0.001), no prescribed controller medication (p<0.001), and clinically stable asthma at enrolment (p=0.002)were significantly associated with low risk of exacerbation during pregnancy, with these combined characteristics only two out of 385 pregnancies were complicated by an exacerbation (OR 0.04, 95% CI 0.01-0.18, p<0.001).

CONCLUSION AND CLINICAL RELEVANCE: Clinically stable asthma at enrolment, together with no history of previous exacerbations and no prescribed controller medication, are determinants of low risk of an asthma exacerbation during pregnancy, which may guide clinicians in individualising surveillance of asthma during pregnancy. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Vol/bind48
Udgave nummer1
Sider (fra-til)23-28
ISSN0954-7894
DOI
StatusUdgivet - sep. 2017

ID: 51696698