TY - JOUR
T1 - Determinants of Depression in the ECLIPSE COPD Cohort
AU - Hanania, Nicola A
AU - Müllerova, Hana
AU - Locantore, Nicholas W
AU - Vestbo, Jørgen
AU - Watkins, Michael L
AU - Wouters, Emiel F M
AU - Rennard, Stephen I
AU - Sharafkhaneh, Amir
AU - NN, NN
PY - 2010
Y1 - 2010
N2 - RATIONALE: Depression is prevalent in patients with chronic obstructive pulmonary disease (COPD); however, its etiology and relationship to the clinical features of COPD are not well understood. Using data from a large cohort, we explored prevalence and determinants of depression in subjects with COPD. METHODS: The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study is an observational three-year multicenter study that enrolled smokers with and without COPD and non-smoker controls. At baseline, several patient-reported outcomes were measured including the Center for Epidemiologic Studies of Depression Scale (CES-D). For the purposes of this analysis, depression was defined as a CES-D score of 16 and higher which reflects a high load of depressive symptoms and has a good correspondence with a clinical diagnosis of major depression. RESULTS: The study cohort consisted of 2118 subjects with COPD, 335 smokers without COPD (smokers) and 243 non-smokers without COPD (non-smokers). Twenty-six percent, 12% and 7% of COPD, smokers and non-smokers, respectively, suffered from depression. In subjects with COPD, higher depression prevalence was seen in females, current smokers and those with severe disease (GOLD-defined). Multivariate modelling of depression determinants in subjects with COPD revealed that increased fatigue, higher SGRQ-C score, younger age, female gender, history of cardiovascular disease and current smoking status were all significantly associated with depression; physiologic and biologic measures were weak or non-significant descriptors. CONCLUSIONS: Depression is more prevalent in subjects with COPD compared to smokers and non-smokers without COPD. Clinical and biological measures were less important determinants of depression in COPD than disease symptoms and quality-of-life. NCT00292552 http://www.clinicaltrials.gov.
AB - RATIONALE: Depression is prevalent in patients with chronic obstructive pulmonary disease (COPD); however, its etiology and relationship to the clinical features of COPD are not well understood. Using data from a large cohort, we explored prevalence and determinants of depression in subjects with COPD. METHODS: The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study is an observational three-year multicenter study that enrolled smokers with and without COPD and non-smoker controls. At baseline, several patient-reported outcomes were measured including the Center for Epidemiologic Studies of Depression Scale (CES-D). For the purposes of this analysis, depression was defined as a CES-D score of 16 and higher which reflects a high load of depressive symptoms and has a good correspondence with a clinical diagnosis of major depression. RESULTS: The study cohort consisted of 2118 subjects with COPD, 335 smokers without COPD (smokers) and 243 non-smokers without COPD (non-smokers). Twenty-six percent, 12% and 7% of COPD, smokers and non-smokers, respectively, suffered from depression. In subjects with COPD, higher depression prevalence was seen in females, current smokers and those with severe disease (GOLD-defined). Multivariate modelling of depression determinants in subjects with COPD revealed that increased fatigue, higher SGRQ-C score, younger age, female gender, history of cardiovascular disease and current smoking status were all significantly associated with depression; physiologic and biologic measures were weak or non-significant descriptors. CONCLUSIONS: Depression is more prevalent in subjects with COPD compared to smokers and non-smokers without COPD. Clinical and biological measures were less important determinants of depression in COPD than disease symptoms and quality-of-life. NCT00292552 http://www.clinicaltrials.gov.
U2 - 10.1164/rccm.201003-0472OC
DO - 10.1164/rccm.201003-0472OC
M3 - Journal article
C2 - 20889909
SN - 1073-449X
VL - 183
SP - 604
EP - 611
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
ER -