Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Determinants of airflow limitation in Danish adults - findings from the Health2006 cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Update on Asthma-COPD Overlap (ACO): A Narrative Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Withdrawal of Inhaled Corticosteroids in Patients with COPD - A Prospective Observational Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Employment Status, Readmission and Mortality After Acute Exacerbation of COPD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The age-specific incidence of type 2 diabetes in Danish elderly adults – the role of size at birth

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  2. DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: the COVID STEROID randomised, placebo-controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background and aim: Airflow limitation may be found in patients with both asthma and COPD and is often associated with more symptoms and poorer outcome. We aimed to identify factors associated with airflow limitation in a well-characterized, population-based sample of adults.

Methods: From the Health2006 cohort, we selected participants aged ≥35 years at enrolment (n=2,959). Airflow limitation was defined as FEV1/FVC < lower limit of normal. Participants with (cases) and without (controls) airflow limitation were compared with regard to self-reported symptoms, medical history, atopy, lung function and exhaled nitric oxide. Between-group differences were analyzed using Chi-square and Mann-Whitney U tests, and effect size was estimated by logistic regression (reported as OR and 95% CI).

Results: We identified 313 cases, majority of which were female, reported poor overall health, physically inactivity and experienced respiratory symptoms within the previous year. The presence of airflow limitation was associated with BMI (OR 3.1 for overweight, P<0.001, CI 1.97-4.78), age (OR 2.3, P<0.001 for age 55+, CI 1.7-3.2), tobacco exposure (OR 1.6, P=0.01, CI 1.1-2.32, and OR 1.76, P=0.019, CI 1.2-2.3 for former and current smokers, respectively), sex (OR 1.6 for being female, P=0.002, CI 1.2-2.2), presence of specific IgE to common aeroallergen(s) (OR 1.4, P=0.041, CI 1.2-2.0), and ever being diagnosed with asthma (OR 1.6, P=0.003, CI 1.3-2.0).

Conclusion: Apart from tobacco exposure and age, the presence of airflow limitation was associated with being overweight, female, sensitized to common aeroallergens or ever having a diagnosis of asthma.

OriginalsprogEngelsk
TidsskriftInternational Journal of Chronic Obstructive Pulmonary Disease
Vol/bind14
Sider (fra-til)713-718
Antal sider6
ISSN1178-2005
DOI
StatusUdgivet - 26 mar. 2019

ID: 57016596