Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study

Stefan H Kreisel; Christian Blahak; Hansjörg Bäzner; Domenico Inzitari; Leonardo Pantoni; Anna Poggesi; Hugues Chabriat; Timo Erkinjuntti; Franz Fazekas; José M Ferro; Peter Langhorne; John O'Brien; Philip Scheltens; Marieke C Visser; Lars-Olof Wahlund; Gunhild Waldemar; Anders Wallin; Michael G Hennerici

doi:10.1159/000350725

Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study

Stefan H Kreisel, Christian Blahak, Hansjörg Bäzner, Domenico Inzitari, Leonardo Pantoni, Anna Poggesi, Hugues Chabriat, Timo Erkinjuntti, Franz Fazekas, José M Ferro, Peter Langhorne, John O'Brien, Philip Scheltens, Marieke C Visser, Lars-Olof Wahlund, Gunhild Waldemar, Anders Wallin, Michael G Hennerici

64 Citationer (Scopus)

Abstract

Cross-sectional studies have shown an association between the severity of age-related white matter change (ARWMC) and lower body motor function. However, the association between prevalent ARWMC and incident deterioration of balance and gait remains insufficiently investigated. This study investigates if the degree of prevalent ARWMC has a differential effect on lower body motor function as it changes over time, hypothesizing that individuals with more severe baseline white matter pathology experience greater clinical deterioration independent of potential confounders. This is of clinical relevance: given the increasing use of neuroimaging, incidental white matter pathology is common; being able to delineate natural trajectories of balance and gait function given ARWMC may improve patient advice and help optimize allocation of care.

Originalsprog	Engelsk
Tidsskrift	Cerebrovascular diseases (Basel, Switzerland)
Vol/bind	35
Udgave nummer	6
Sider (fra-til)	544-53
Antal sider	10
DOI	https://doi.org/10.1159/000350725
Status	Udgivet - 2013

Adgang til dokumentet

10.1159/000350725

Citationsformater

Kreisel, S. H., Blahak, C., Bäzner, H., Inzitari, D., Pantoni, L., Poggesi, A., Chabriat, H., Erkinjuntti, T., Fazekas, F., Ferro, J. M., Langhorne, P., O'Brien, J., Scheltens, P., Visser, M. C., Wahlund, L.-O., Waldemar, G., Wallin, A., & Hennerici, M. G. (2013). Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study. Cerebrovascular diseases (Basel, Switzerland), 35(6), 544-53. https://doi.org/10.1159/000350725

Kreisel, SH, Blahak, C, Bäzner, H, Inzitari, D, Pantoni, L, Poggesi, A, Chabriat, H, Erkinjuntti, T, Fazekas, F, Ferro, JM, Langhorne, P, O'Brien, J, Scheltens, P, Visser, MC, Wahlund, L-O, Waldemar, G, Wallin, A & Hennerici, MG 2013, 'Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study', Cerebrovascular diseases (Basel, Switzerland), bind 35, nr. 6, s. 544-53. https://doi.org/10.1159/000350725

@article{944e697ff6fa438b81f6c13592f36006,

title = "Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study",

abstract = "Cross-sectional studies have shown an association between the severity of age-related white matter change (ARWMC) and lower body motor function. However, the association between prevalent ARWMC and incident deterioration of balance and gait remains insufficiently investigated. This study investigates if the degree of prevalent ARWMC has a differential effect on lower body motor function as it changes over time, hypothesizing that individuals with more severe baseline white matter pathology experience greater clinical deterioration independent of potential confounders. This is of clinical relevance: given the increasing use of neuroimaging, incidental white matter pathology is common; being able to delineate natural trajectories of balance and gait function given ARWMC may improve patient advice and help optimize allocation of care.",

author = "Kreisel, {Stefan H} and Christian Blahak and Hansj{\"o}rg B{\"a}zner and Domenico Inzitari and Leonardo Pantoni and Anna Poggesi and Hugues Chabriat and Timo Erkinjuntti and Franz Fazekas and Ferro, {Jos{\'e} M} and Peter Langhorne and John O'Brien and Philip Scheltens and Visser, {Marieke C} and Lars-Olof Wahlund and Gunhild Waldemar and Anders Wallin and Hennerici, {Michael G}",

note = "Copyright {\textcopyright} 2013 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000350725",

language = "English",

volume = "35",

pages = "544--53",

journal = "Cerebrovascular diseases (Basel, Switzerland)",

issn = "1421-9786",

publisher = "S./Karger AG",

number = "6",

}

TY - JOUR

T1 - Deterioration of gait and balance over time

T2 - the effects of age-related white matter change--the LADIS study

AU - Kreisel, Stefan H

AU - Blahak, Christian

AU - Bäzner, Hansjörg

AU - Inzitari, Domenico

AU - Pantoni, Leonardo

AU - Poggesi, Anna

AU - Chabriat, Hugues

AU - Erkinjuntti, Timo

AU - Fazekas, Franz

AU - Ferro, José M

AU - Langhorne, Peter

AU - O'Brien, John

AU - Scheltens, Philip

AU - Visser, Marieke C

AU - Wahlund, Lars-Olof

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Hennerici, Michael G

PY - 2013

Y1 - 2013

N2 - Cross-sectional studies have shown an association between the severity of age-related white matter change (ARWMC) and lower body motor function. However, the association between prevalent ARWMC and incident deterioration of balance and gait remains insufficiently investigated. This study investigates if the degree of prevalent ARWMC has a differential effect on lower body motor function as it changes over time, hypothesizing that individuals with more severe baseline white matter pathology experience greater clinical deterioration independent of potential confounders. This is of clinical relevance: given the increasing use of neuroimaging, incidental white matter pathology is common; being able to delineate natural trajectories of balance and gait function given ARWMC may improve patient advice and help optimize allocation of care.

AB - Cross-sectional studies have shown an association between the severity of age-related white matter change (ARWMC) and lower body motor function. However, the association between prevalent ARWMC and incident deterioration of balance and gait remains insufficiently investigated. This study investigates if the degree of prevalent ARWMC has a differential effect on lower body motor function as it changes over time, hypothesizing that individuals with more severe baseline white matter pathology experience greater clinical deterioration independent of potential confounders. This is of clinical relevance: given the increasing use of neuroimaging, incidental white matter pathology is common; being able to delineate natural trajectories of balance and gait function given ARWMC may improve patient advice and help optimize allocation of care.

U2 - 10.1159/000350725

DO - 10.1159/000350725

M3 - Journal article

C2 - 23838682

SN - 1421-9786

VL - 35

SP - 544

EP - 553

JO - Cerebrovascular diseases (Basel, Switzerland)

JF - Cerebrovascular diseases (Basel, Switzerland)

IS - 6

ER -

Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater