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Region Hovedstaden - en del af Københavns Universitetshospital
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Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Urszula Nawrot
  • Ewelina Kurzyk
  • Maiken Cavling Arendrup
  • Martyna Mroczynska
  • Katarzyna Wlodarczyk
  • Beata Sulik-Tyszka
  • Marta Wróblewska
  • Marek Ussowicz
  • Przemyslaw Zdziarski
  • Kinga Niewinska
  • Anna Brillowska-Dabrowska
Vis graf over relationer

We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wrocław, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.

OriginalsprogEngelsk
TidsskriftMedical Mycology
Vol/bind56
Udgave nummer1
Sider (fra-til)121-124
Antal sider4
ISSN1369-3786
DOI
StatusUdgivet - 2018

ID: 52080793