Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Henrik E Poulsen; Laia Llovera Nadal; Kasper Broedbaek; Peter Nielsen; Allan Weimann

doi:10.1016/j.bbagen.2013.06.009

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Henrik E Poulsen, Laia Llovera Nadal, Kasper Broedbaek, Peter Nielsen, Allan Weimann

Klinisk Farmakologisk Afd.

138 Citationer (Scopus)

Abstract

DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.

Originalsprog	Engelsk
Tidsskrift	Biochimica et Biophysica Acta
Vol/bind	1840
Udgave nummer	2
Sider (fra-til)	801-808
Antal sider	8
ISSN	0006-3002
DOI	https://doi.org/10.1016/j.bbagen.2013.06.009
Status	Udgivet - feb. 2014

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10.1016/j.bbagen.2013.06.009

Citationsformater

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title = "Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid",

abstract = "DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.",

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T1 - Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

AU - Poulsen, Henrik E

AU - Nadal, Laia Llovera

AU - Broedbaek, Kasper

AU - Nielsen, Peter

AU - Weimann, Allan

PY - 2014/2

Y1 - 2014/2

N2 - DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.

AB - DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.

U2 - 10.1016/j.bbagen.2013.06.009

DO - 10.1016/j.bbagen.2013.06.009

M3 - Journal article

C2 - 23791936

SN - 0006-3002

VL - 1840

SP - 801

EP - 808

JO - Biochimica et Biophysica Acta

JF - Biochimica et Biophysica Acta

IS - 2

ER -

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Abstract

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