Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Henrik E Poulsen, Laia Llovera Nadal, Kasper Broedbaek, Peter Nielsen, Allan Weimann

Abstract

DNA and RNA oxidations have been linked to diseases such as cancer, arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied is the 8-hydroxylation of guanine. DNA integrity is maintained by elaborate repair systems and RNA integrity is less studied but relies mainly on degradation.
OriginalsprogEngelsk
TidsskriftBiochimica et Biophysica Acta
Vol/bind1840
Udgave nummer2
Sider (fra-til)801-808
Antal sider8
ISSN0006-3002
DOI
StatusUdgivet - feb. 2014

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