Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  1. Surveying the global virome: Identification and characterization of HCV-related animal hepaciviruses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Serum amyloid P component inhibits influenza A virus infections: in vitro and in vivo studies.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Inhibition of HIV-1 in vitro by C-5 propyne phosphorothioate antisense to rev.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  4. Effect of anti-carbohydrate antibodies on HIV infection in a monocytic cell line (U937).

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  1. Primary resistance to integrase strand-transfer inhibitors in Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Why START? Reflections that led to the conduct of this large long-term strategic HIV trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of HIV or second syphilis infection in Danish men with newly acquired syphilis in the period 2000-2010

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.
Bidragets oversatte titelDerivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.
OriginalsprogEngelsk
TidsskriftAntiviral Research
Vol/bind14
Udgave nummer3
Sider (fra-til)149-159
Antal sider11
ISSN0166-3542
StatusUdgivet - 1990

ID: 32506081