Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.:

J E Hansen; N M Witzke; C Nielsen; Lars Reinhardt Mathiesen; L S Teglbjaerg; C M Nielsen; Jens Ole Nielsen

Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

Bidragets oversatte titel: Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

J E Hansen, N M Witzke, C Nielsen, Lars Reinhardt Mathiesen, L S Teglbjaerg, C M Nielsen, Jens Ole Nielsen

Infektionsmedicinsk Afdeling

15 Citationer (Scopus)

Abstract

Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

Bidragets oversatte titel	Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.
Originalsprog	Engelsk
Tidsskrift	Antiviral Research
Vol/bind	14
Udgave nummer	3
Sider (fra-til)	149-159
Antal sider	11
ISSN	0166-3542
Status	Udgivet - 1990

Adgang til dokumentet

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2080870&query_hl=103

Citationsformater

Hansen, J. E., Witzke, N. M., Nielsen, C., Mathiesen, L. R., Teglbjaerg, L. S., Nielsen, C. M., & Nielsen, J. O. (1990). Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. Antiviral Research, 14(3), 149-159. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2080870&query_hl=103

Hansen, JE, Witzke, NM, Nielsen, C, Mathiesen, LR, Teglbjaerg, LS, Nielsen, CM & Nielsen, JO 1990, 'Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.', Antiviral Research, bind 14, nr. 3, s. 149-159. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2080870&query_hl=103>

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title = "Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.",

abstract = "Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N{"}-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N{"}-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.",

author = "Hansen, {J E} and Witzke, {N M} and C Nielsen and Mathiesen, {Lars Reinhardt} and Teglbjaerg, {L S} and Nielsen, {C M} and Nielsen, {Jens Ole}",

year = "1990",

language = "English",

volume = "14",

pages = "149--159",

journal = "Antiviral Research",

issn = "0166-3542",

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T1 - Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.

AU - Hansen, J E

AU - Witzke, N M

AU - Nielsen, C

AU - Mathiesen, Lars Reinhardt

AU - Teglbjaerg, L S

AU - Nielsen, C M

AU - Nielsen, Jens Ole

PY - 1990

Y1 - 1990

N2 - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

AB - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.

M3 - Journal article

SN - 0166-3542

VL - 14

SP - 149

EP - 159

JO - Antiviral Research

JF - Antiviral Research

IS - 3

ER -