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Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study

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Clausen, MR, Ulrichsen, SP, Larsen, TS, Poulsen, CB, Tojaga, S, Pedersen, PT, Madsen, J, Pedersen, RS, Josefsson, PL, Gørløv, JS, Nørgaard, M & d'Amore, F 2019, 'Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study' Leukemia and Lymphoma, bind 60, nr. 8, s. 1950-1957. https://doi.org/10.1080/10428194.2018.1554863

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Author

Clausen, Michael Roost ; Ulrichsen, Sinna Pilgaard ; Larsen, Thomas Stauffer ; Poulsen, Christian B ; Tojaga, Selma ; Pedersen, Per Trøllund ; Madsen, Jakob ; Pedersen, Robert Schou ; Josefsson, Pär Lars ; Gørløv, Jette Sønderskov ; Nørgaard, Mette ; d'Amore, Francesco. / Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study. I: Leukemia and Lymphoma. 2019 ; Bind 60, Nr. 8. s. 1950-1957.

Bibtex

@article{e71f7c9e0bd74059a31e3be21ba7c730,
title = "Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study",
abstract = "We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45{\%}). Grade 0 patients had a 5-year overall survival of 67{\%}, grade 1-2: 78{\%}, grade 3: 64{\%}, and grade 4: 57{\%}. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95{\%} CI 0.49-1.21) for grade 1-2, 1.18 (95{\%} CI 0.82-1.71) for grade 3, and 1.33 (95{\%} CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.",
author = "Clausen, {Michael Roost} and Ulrichsen, {Sinna Pilgaard} and Larsen, {Thomas Stauffer} and Poulsen, {Christian B} and Selma Tojaga and Pedersen, {Per Tr{\o}llund} and Jakob Madsen and Pedersen, {Robert Schou} and Josefsson, {P{\"a}r Lars} and G{\o}rl{\o}v, {Jette S{\o}nderskov} and Mette N{\o}rgaard and Francesco d'Amore",
year = "2019",
month = "7",
day = "3",
doi = "10.1080/10428194.2018.1554863",
language = "English",
volume = "60",
pages = "1950--1957",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "8",

}

RIS

TY - JOUR

T1 - Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study

AU - Clausen, Michael Roost

AU - Ulrichsen, Sinna Pilgaard

AU - Larsen, Thomas Stauffer

AU - Poulsen, Christian B

AU - Tojaga, Selma

AU - Pedersen, Per Trøllund

AU - Madsen, Jakob

AU - Pedersen, Robert Schou

AU - Josefsson, Pär Lars

AU - Gørløv, Jette Sønderskov

AU - Nørgaard, Mette

AU - d'Amore, Francesco

PY - 2019/7/3

Y1 - 2019/7/3

N2 - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.

AB - We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.

U2 - 10.1080/10428194.2018.1554863

DO - 10.1080/10428194.2018.1554863

M3 - Journal article

VL - 60

SP - 1950

EP - 1957

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 8

ER -

ID: 57443545