Depressed natural killer cell activity in acute myocardial infarction

K. Klarlund; B. K. Pedersen; T. G. Theander; V. Andersen

Depressed natural killer cell activity in acute myocardial infarction

K. Klarlund, B. K. Pedersen, T. G. Theander, V. Andersen

22 Citationer (Scopus)

Abstract

Natural killer (NK) cell activity against K562 target cells was measured in patients within 24 h of acute myocardial infarction (AMI) and regularly thereafter for 6 weeks. NK cell activity was suppressed on days 1, 3, and 7 (P < 0.01), day 14 (P < 0.05) and at 6 weeks (P = 0.05) when compared to controls. Interferon, interleukin 2 and indomethacin enhanced NK cell activity on all days measured, but did not completely restore the defective NK cell activity. Serum from the patients did not suppress the NK cell activity of healthy mononuclear cells. The number of NK cells, identified as large granular lymphocytes (LGL), measured on days 1, 3, and 14 and at 6 weeks was not reduced in comparison to that of controls. Thus, the defective NK cell activity can be characterized as functional.

Originalsprog	Engelsk
Tidsskrift	Clinical and Experimental Immunology
Vol/bind	70
Udgave nummer	1
Sider (fra-til)	209-216
Antal sider	8
ISSN	0009-9104
Status	Udgivet - 1987
Udgivet eksternt	Ja

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title = "Depressed natural killer cell activity in acute myocardial infarction",

abstract = "Natural killer (NK) cell activity against K562 target cells was measured in patients within 24 h of acute myocardial infarction (AMI) and regularly thereafter for 6 weeks. NK cell activity was suppressed on days 1, 3, and 7 (P < 0.01), day 14 (P < 0.05) and at 6 weeks (P = 0.05) when compared to controls. Interferon, interleukin 2 and indomethacin enhanced NK cell activity on all days measured, but did not completely restore the defective NK cell activity. Serum from the patients did not suppress the NK cell activity of healthy mononuclear cells. The number of NK cells, identified as large granular lymphocytes (LGL), measured on days 1, 3, and 14 and at 6 weeks was not reduced in comparison to that of controls. Thus, the defective NK cell activity can be characterized as functional.",

author = "K. Klarlund and Pedersen, {B. K.} and Theander, {T. G.} and V. Andersen",

year = "1987",

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T1 - Depressed natural killer cell activity in acute myocardial infarction

AU - Klarlund, K.

AU - Pedersen, B. K.

AU - Theander, T. G.

AU - Andersen, V.

PY - 1987

Y1 - 1987

N2 - Natural killer (NK) cell activity against K562 target cells was measured in patients within 24 h of acute myocardial infarction (AMI) and regularly thereafter for 6 weeks. NK cell activity was suppressed on days 1, 3, and 7 (P < 0.01), day 14 (P < 0.05) and at 6 weeks (P = 0.05) when compared to controls. Interferon, interleukin 2 and indomethacin enhanced NK cell activity on all days measured, but did not completely restore the defective NK cell activity. Serum from the patients did not suppress the NK cell activity of healthy mononuclear cells. The number of NK cells, identified as large granular lymphocytes (LGL), measured on days 1, 3, and 14 and at 6 weeks was not reduced in comparison to that of controls. Thus, the defective NK cell activity can be characterized as functional.

AB - Natural killer (NK) cell activity against K562 target cells was measured in patients within 24 h of acute myocardial infarction (AMI) and regularly thereafter for 6 weeks. NK cell activity was suppressed on days 1, 3, and 7 (P < 0.01), day 14 (P < 0.05) and at 6 weeks (P = 0.05) when compared to controls. Interferon, interleukin 2 and indomethacin enhanced NK cell activity on all days measured, but did not completely restore the defective NK cell activity. Serum from the patients did not suppress the NK cell activity of healthy mononuclear cells. The number of NK cells, identified as large granular lymphocytes (LGL), measured on days 1, 3, and 14 and at 6 weeks was not reduced in comparison to that of controls. Thus, the defective NK cell activity can be characterized as functional.

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M3 - Journal article

C2 - 3500813

AN - SCOPUS:0023270190

SN - 0009-9104

VL - 70

SP - 209

EP - 216

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 1

ER -

Depressed natural killer cell activity in acute myocardial infarction

Abstract

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