Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Demographic, lifestyle and comorbid risk factors for all-cause mortality in a Danish cohort of middle-aged adults with incident asthma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: the COVID STEROID randomised, placebo-controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characteristics of COPD Patients Prescribed ICS Managed in General Practice vs. Secondary Care

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Management of anaphylaxis due to COVID-19 vaccines in the elderly

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: We aimed to identify factors associated with all-cause mortality in adults with incident asthma.

DESIGN AND SETTING: Cross-sectional cohort study, in the metropolitan areas of Copenhagen and Aarhus, Denmark.

PARTICIPANTS: Adults aged 50-64 years enrolled in the Danish Diet, Cancer, and Health cohort were followed up from baseline (1993-1997) in the National Patients Registry for first-time admissions for asthma and vital status. We defined incident asthma as at least one first-time hospital admission with asthma as the primary registered diagnosis between baseline and end of follow-up (2013) in participants without previously known asthma. Among the cohort comprising 57 053 individuals, we identified 785 adults (aged 50-64) with incident asthma, of whom 76 died during follow-up.

PRIMARY AND SECONDARY OUTCOME MEASURES: Baseline reported socioeconomic and lifestyle traits, and comorbidities associated with all-cause mortality.

RESULTS: Self-reported leisure-time physical activity was associated with a substantial reduction in risk with an HR of 0.53 (95% CI 0.33 to 0.85). Being male, single and having a diagnosis of hypertension or diabetes were associated with an increased risk of all-cause mortality with an HR of 1.83 (95% CI 1.14 to 2.38), 2.16 (95% CI 2.06 to 4.40), 2.47 (95% CI 1.54 to 3.95) and of 2.42 (95% CI 0.96 to 6.11), respectively.

CONCLUSIONS: This long-term study of adults with hospital contacts for incident asthma revealed that self-reported leisure-time physical activity is associated with an approximately 50% reduction in all-cause mortality. In contrast, both hypertension and diabetes were associated with a higher risk of mortality.

OriginalsprogEngelsk
Artikelnummere049243
TidsskriftBMJ Open
Vol/bind11
Udgave nummer10
ISSN2044-6055
DOI
StatusUdgivet - 4 okt. 2021

Bibliografisk note

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 68332565