Delayed Breast Implant Reconstruction: Is Radiation Therapy Associated With Capsular Contracture or Reoperations?

Gitte Bjørn Hvilsom, Lisbet Rosenkrantz Hölmich, Marianne Steding-Jessen, Kirsten Frederiksen, Trine Foged Henriksen, Loren Lipworth, Joseph McLaughlin, Jens Jørgen Elberg, Tine Engberg Damsgaard, Søren Friis

51 Citationer (Scopus)

Abstract

We evaluated the association between radiation therapy and severe capsular contracture or reoperation after 717 delayed breast implant reconstruction procedures (288 1- and 429 2-stage procedures) identified in the prospective database of the Danish Registry for Plastic Surgery of the Breast during the period between 1999 and 2006. A history of radiation therapy was associated with increased risk of severe capsular contracture for 1- and 2-stage procedures, with adjusted hazard ratios (HR) of 3.3 (95% confidence interval [CI]: 0.9-12.4) and 7.2 (95% CI: 2.4-21.4), respectively. Similarly, a history of radiation therapy was associated with a non-significantly increased risk of reoperation after both 1-stage (HR = 1.4; 95% CI: 0.7-2.5) and 2-stage (HR = 1.6; 95% CI: 0.9-3.1) procedures. Reconstruction failure was highest (13.2%) in the 2-stage procedures with a history of radiation therapy. Breast reconstruction approaches other than implants should be seriously considered among women who have received radiation therapy.
OriginalsprogEngelsk
TidsskriftAnnals of Plastic Surgery
Vol/bindVolume 68(3)
Sider (fra-til)246–252
ISSN0148-7043
DOI
StatusUdgivet - mar. 2012

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