TY - JOUR
T1 - Delayed Breast Implant Reconstruction: Is Radiation Therapy Associated With Capsular Contracture or Reoperations?
AU - Hvilsom, Gitte Bjørn
AU - Hölmich, Lisbet Rosenkrantz
AU - Steding-Jessen, Marianne
AU - Frederiksen, Kirsten
AU - Henriksen, Trine Foged
AU - Lipworth, Loren
AU - McLaughlin, Joseph
AU - Elberg, Jens Jørgen
AU - Damsgaard, Tine Engberg
AU - Friis, Søren
PY - 2012/3
Y1 - 2012/3
N2 - We evaluated the association between radiation therapy and severe capsular contracture or reoperation after 717 delayed breast implant reconstruction procedures (288 1- and 429 2-stage procedures) identified in the prospective database of the Danish Registry for Plastic Surgery of the Breast during the period between 1999 and 2006. A history of radiation therapy was associated with increased risk of severe capsular contracture for 1- and 2-stage procedures, with adjusted hazard ratios (HR) of 3.3 (95% confidence interval [CI]: 0.9-12.4) and 7.2 (95% CI: 2.4-21.4), respectively. Similarly, a history of radiation therapy was associated with a non-significantly increased risk of reoperation after both 1-stage (HR = 1.4; 95% CI: 0.7-2.5) and 2-stage (HR = 1.6; 95% CI: 0.9-3.1) procedures. Reconstruction failure was highest (13.2%) in the 2-stage procedures with a history of radiation therapy. Breast reconstruction approaches other than implants should be seriously considered among women who have received radiation therapy.
AB - We evaluated the association between radiation therapy and severe capsular contracture or reoperation after 717 delayed breast implant reconstruction procedures (288 1- and 429 2-stage procedures) identified in the prospective database of the Danish Registry for Plastic Surgery of the Breast during the period between 1999 and 2006. A history of radiation therapy was associated with increased risk of severe capsular contracture for 1- and 2-stage procedures, with adjusted hazard ratios (HR) of 3.3 (95% confidence interval [CI]: 0.9-12.4) and 7.2 (95% CI: 2.4-21.4), respectively. Similarly, a history of radiation therapy was associated with a non-significantly increased risk of reoperation after both 1-stage (HR = 1.4; 95% CI: 0.7-2.5) and 2-stage (HR = 1.6; 95% CI: 0.9-3.1) procedures. Reconstruction failure was highest (13.2%) in the 2-stage procedures with a history of radiation therapy. Breast reconstruction approaches other than implants should be seriously considered among women who have received radiation therapy.
U2 - 10.1097/SAP.0b013e318214e69c
DO - 10.1097/SAP.0b013e318214e69c
M3 - Journal article
C2 - 21540726
SN - 0148-7043
VL - Volume 68(3)
SP - 246
EP - 252
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
ER -