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Udgivet

Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Substantial Lymphovascular Space Invasion Is an Adverse Prognostic Factor in High-risk Endometrial Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Glycogen Storage Disease Type IV: A Case With Histopathologic Findings in First-Trimester Placental Tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. History of gynecological pathology XXV. Dr Gunnar Teilum

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Prognostic Value of Plasma Small Extracellular Vesicles' Phenotype in Patients With Gastrointestinal Stromal Tumor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pre-and Postoperative Circulating Tumour DNA in Patients With Gastrointestinal Stromal Tumour - A Methodological Assessment Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Potential Targeted Therapies in Ovarian Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. An overview of Clinical Quality Registries (CQRs) on gynecological oncology worldwide

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Lymphovascular space invasion (LVSI) occurs in a minority of endometrial cancer (EC) cases, and the extent of LVSI is an important risk factor for recurrence and/or metastases. Our aim was to improve the reproducibility of measuring clinically meaningful LVSI by performing a quantitative analysis of the correlation between LVSI and the risk of pelvic lymph node recurrence in EC. EC samples from PORTEC-1 and PORTEC-2 trials were retrieved and used to collect quantitative data, including the number of LVSI-positive vessels per H&E-stained slide. Using a predefined threshold for clinical relevance, the risk of pelvic lymph node recurrence risk was calculated (Kaplan-Meier method, with Cox regression) using a stepwise adjustment for the number of LVSI-positive vessels. This analysis was then repeated in the Danish Gynecological Cancer Database (DGCD) cohort. Among patients in PORTEC-1 and PORTEC-2 trials who did not receive external beam radiotherapy, the 5-yr pelvic lymph node recurrence risk was 3.3%, 6.7% (P=0.51), and 26.3% (P<0.001), respectively when 0, 1 to 3, or ≥4 vessels had LVSI involvement; similar results were obtained for the DGCD cohort. Furthermore, both the average number of tumor cells in the largest embolus and the number of LVSI-positive H&E slides differed significantly between focal LVSI and substantial LVSI. On the basis of these results, we propose a numeric threshold (≥4 LVSI-involved vessels in at least one H&E slide) for defining clinically relevant LVSI in EC, thereby adding supportive data to the semiquantitative approach. This will help guide gynecologic pathologists to differentiate between focal and substantial LVSI, especially in borderline cases.

OriginalsprogEngelsk
TidsskriftInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Vol/bind41
Udgave nummer3
Sider (fra-til)220-226
Antal sider7
ISSN0277-1691
DOI
StatusUdgivet - 1 maj 2022

Bibliografisk note

Copyright ©2021International Society of Gynecological Pathologists.

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