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Defective Natural Killer cell antiviral capacity in paediatric HBV infection

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@article{5a887862c2bd4e078d514a382140737b,
title = "Defective Natural Killer cell antiviral capacity in paediatric HBV infection",
abstract = "Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.",
author = "Heiberg, {Ida Louise} and {Laura J.}, Pallett and Winther, {Thilde Nordmann} and Birthe H{\o}gh and Maini, {Mala K.} and Dimitra Peppa",
note = "Clinical & Experimental Immunology Volume 179, Issue 3, pages 466–476, March 2015",
year = "2015",
doi = "10.1111/cei.12470",
language = "English",
volume = "179",
pages = "466–476",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Defective Natural Killer cell antiviral capacity in paediatric HBV infection

AU - Heiberg, Ida Louise

AU - Laura J., Pallett

AU - Winther, Thilde Nordmann

AU - Høgh, Birthe

AU - Maini, Mala K.

AU - Peppa, Dimitra

N1 - Clinical & Experimental Immunology Volume 179, Issue 3, pages 466–476, March 2015

PY - 2015

Y1 - 2015

N2 - Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.

AB - Natural Killer (NK) cells exhibit dysregulated effector function in adult chronic HBV infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell IFN-γ production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-Dendritic Cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-γ production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of antiviral therapy aiming to restore immune control.

U2 - 10.1111/cei.12470

DO - 10.1111/cei.12470

M3 - Journal article

VL - 179

SP - 466

EP - 476

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -

ID: 44760192