Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention

Jeanne D Johansen; Niels Veien; Grete Laurberg; Christian Avnstorp; Knud Kaaber; Klaus E Andersen; Evy Paulsen; Mette Sommerlund; Jens Thormann; Niels H Nielsen; Susanne Vissing; Ove Kristensen; Berit Kristensen; Tove Agner; Torkil Menné

doi:10.1111/j.1600-0536.2008.01364.x

Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention

Jeanne D Johansen, Niels Veien, Grete Laurberg, Christian Avnstorp, Knud Kaaber, Klaus E Andersen, Evy Paulsen, Mette Sommerlund, Jens Thormann, Niels H Nielsen, Susanne Vissing, Ove Kristensen, Berit Kristensen, Tove Agner, Torkil Menné

73 Citationer (Scopus)

Abstract

BACKGROUND: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy.

OBJECTIVES: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions.

PATIENTS/METHODS: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet.

RESULTS: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001).

CONCLUSIONS: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	59
Udgave nummer	1
Sider (fra-til)	48-51
Antal sider	4
ISSN	0105-1873
DOI	https://doi.org/10.1111/j.1600-0536.2008.01364.x
Status	Udgivet - jul. 2008

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10.1111/j.1600-0536.2008.01364.x

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Johansen, J. D., Veien, N., Laurberg, G., Avnstorp, C., Kaaber, K., Andersen, K. E., Paulsen, E., Sommerlund, M., Thormann, J., Nielsen, N. H., Vissing, S., Kristensen, O., Kristensen, B., Agner, T., & Menné, T. (2008). Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention. Contact Dermatitis, 59(1), 48-51. https://doi.org/10.1111/j.1600-0536.2008.01364.x

Johansen, JD, Veien, N, Laurberg, G, Avnstorp, C, Kaaber, K, Andersen, KE, Paulsen, E, Sommerlund, M, Thormann, J, Nielsen, NH, Vissing, S, Kristensen, O, Kristensen, B, Agner, T & Menné, T 2008, 'Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention', Contact Dermatitis, bind 59, nr. 1, s. 48-51. https://doi.org/10.1111/j.1600-0536.2008.01364.x

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title = "Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention",

abstract = "BACKGROUND: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy.OBJECTIVES: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions.PATIENTS/METHODS: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet.RESULTS: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001).CONCLUSIONS: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.",

keywords = "Adult, Consumer Product Safety, Cosmetics, Denmark, Dermatitis, Allergic Contact, Environmental Exposure, European Union, Female, Government Regulation, Humans, Male, Middle Aged, Nitriles, Patch Tests, Population Surveillance, Predictive Value of Tests, Preservatives, Pharmaceutical, Prevalence, Journal Article",

author = "Johansen, {Jeanne D} and Niels Veien and Grete Laurberg and Christian Avnstorp and Knud Kaaber and Andersen, {Klaus E} and Evy Paulsen and Mette Sommerlund and Jens Thormann and Nielsen, {Niels H} and Susanne Vissing and Ove Kristensen and Berit Kristensen and Tove Agner and Torkil Menn{\'e}",

year = "2008",

month = jul,

doi = "10.1111/j.1600-0536.2008.01364.x",

language = "English",

volume = "59",

pages = "48--51",

journal = "Contact Dermatitis",

issn = "0105-1873",

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TY - JOUR

T1 - Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention

AU - Johansen, Jeanne D

AU - Veien, Niels

AU - Laurberg, Grete

AU - Avnstorp, Christian

AU - Kaaber, Knud

AU - Andersen, Klaus E

AU - Paulsen, Evy

AU - Sommerlund, Mette

AU - Thormann, Jens

AU - Nielsen, Niels H

AU - Vissing, Susanne

AU - Kristensen, Ove

AU - Kristensen, Berit

AU - Agner, Tove

AU - Menné, Torkil

PY - 2008/7

Y1 - 2008/7

N2 - BACKGROUND: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy.OBJECTIVES: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions.PATIENTS/METHODS: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet.RESULTS: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001).CONCLUSIONS: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

AB - BACKGROUND: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy.OBJECTIVES: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions.PATIENTS/METHODS: The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet.RESULTS: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001).CONCLUSIONS: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

KW - Adult

KW - Consumer Product Safety

KW - Cosmetics

KW - Denmark

KW - Dermatitis, Allergic Contact

KW - Environmental Exposure

KW - European Union

KW - Female

KW - Government Regulation

KW - Humans

KW - Male

KW - Middle Aged

KW - Nitriles

KW - Patch Tests

KW - Population Surveillance

KW - Predictive Value of Tests

KW - Preservatives, Pharmaceutical

KW - Prevalence

KW - Journal Article

U2 - 10.1111/j.1600-0536.2008.01364.x

DO - 10.1111/j.1600-0536.2008.01364.x

M3 - Journal article

C2 - 18537990

SN - 0105-1873

VL - 59

SP - 48

EP - 51

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention

Abstract

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