Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Decreased leakage rate of colonic anastomoses by tachosil coating: an experimental study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fluorescence guided intraluminal endoscopy in the gastrointestinal tract: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. More than one-third of Cochrane reviews had gift authors, whereas ghost authorship was rare

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Group authorships in Cochrane had low compliance with Cochrane recommendations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Abstract Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P = 0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P < 0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P = 0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.

TidsskriftInternational Surgery
Udgave nummer4
Sider (fra-til)359-63
Antal sider5
StatusUdgivet - 25 jul. 2014

ID: 44543029